Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3699913..3700567 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag KYC43_RS18155 Protein ID WP_000244774.1
Coordinates 3699913..3700320 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KYC43_RS18160 Protein ID WP_000354046.1
Coordinates 3700301..3700567 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS18135 (3695870) 3695870..3697603 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
KYC43_RS18140 (3697609) 3697609..3698319 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KYC43_RS18145 (3698344) 3698344..3699240 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KYC43_RS18150 (3699352) 3699352..3699873 + 522 WP_001055874.1 flavodoxin FldB -
KYC43_RS18155 (3699913) 3699913..3700320 - 408 WP_000244774.1 protein YgfX Toxin
KYC43_RS18160 (3700301) 3700301..3700567 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KYC43_RS18165 (3700819) 3700819..3701799 + 981 WP_000886103.1 tRNA-modifying protein YgfZ -
KYC43_RS18170 (3701876) 3701876..3702535 - 660 WP_000250283.1 hemolysin III family protein -
KYC43_RS18175 (3702699) 3702699..3703010 - 312 WP_001182962.1 N(4)-acetylcytidine aminohydrolase -
KYC43_RS18180 (3703055) 3703055..3704488 + 1434 WP_024256637.1 6-phospho-beta-glucosidase BglA -
KYC43_RS18185 (3704536) 3704536..3705429 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T210297 WP_000244774.1 NZ_CP079884:c3700320-3699913 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T210297 NZ_CP104491:c764366-763437 [Salmonella enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTTAGGCTATTAATGGCTGCGCTGCCGCATGTGGCAAAGGAGTCTTGCTT
CGCCCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTCCCTCGCCTGTCGGTAGATATCGATCTGGCGTATA
AGGCCTATGCGGATCGCGATACCGATCTGGCTACCATCAATGACGCCTTGATGCGTATTACTGAATCACTGAACGGCAGA
CCGGGGATCACCGCTATCCGGCAGGAGAACAAAGCGGATGAAAAGCGCATCATTGTTAACACCGCCGACGCGCAGATAAA
GATTGAAGTTAGCCCAGTCTGGCGTGGGCTGCTGTTGCCAGCAACAGAAATGCCGGTATGTGAACAGGTGGAAATGGAGT
ATGGCTTCACCACGATGAATGTCGTCTCGCAGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTACTGAATATGCTGGAGAAACCGGGCCTGACGCGCGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCGCCGAACTGGGATACATCGCGGATCGCAACTCTTTACGCAC
AGGAATTTTCAGGAATGACGCAGCGGGAAACATCGCTGGAGTCACTTTTATCAGTAACGACTTTGCTGCCACAAACGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCAGCTATAAGCAAATTACCCCTGACTGGTCGCTGTATCGCTA
TCCTGGAATTCAACACCTACCGGCTATTCGCTGGAAGCTGCGTAATCTGGCGGTACTGAAGGAAAAGAACCCGGCCAAGT
ATGCGGCGACGGTGAACAAGTTAGAAGGCGTTCTGGAGCAGTACTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT210297 WP_000354046.1 NZ_CP079884:c3700567-3700301 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210297 NZ_CP104491:c765135-764353 [Salmonella enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAGAACACCCAACCCGGTCAGGTGTTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GCCGTGAGCCAGACTGGGTGGACGCGGTTTATTGCCTGCAAACGCAGTGGGAAAAACCGGTTCGCGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCCCACTATACCGAACCGGGTAAACCACAGGTCTGGCTCGCGCTTCCGGCTTATGTCAA
GCTGCCGGGATGGTTCGCCGCCTTTGAACAATCCGCGATGTTTGTCACGCTGTATACCTCTGGCCTCACCGTTGATGTAA
CACCATTTACGACAACACTGAATATCGGCGACCGACAGTTAACAGGCAGTGTCCCGGAACTGGCCGCTTATGAGATCGCC
GGCGGTGTTCCCTCGTTGATCTCATTCGAACATGCCGATGCGCTGTTTCAGGGGATGAACCTTCTCAGCCCGCGTAAATT
ACAGACACTGCTCTGCGCCAGCCATTCGGTTAAAACCAACCGGGTAATGCTCTATCTTGCCCGGCGCAATGAGCATCCTT
ATTTTCGGTATCTCGATCAAAGCGATATAGAAACAGGTACGGGAAAGCGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References