Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1247235..1247914 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name higB Uniprot ID A0A0A1A1R1
Locus tag KYC43_RS06150 Protein ID WP_000057541.1
Coordinates 1247235..1247537 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag KYC43_RS06155 Protein ID WP_000806442.1
Coordinates 1247573..1247914 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS06125 (1242611) 1242611..1244263 + 1653 WP_182212215.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
KYC43_RS06130 (1244301) 1244301..1244804 - 504 WP_000667001.1 hypothetical protein -
KYC43_RS06135 (1244801) 1244801..1245601 - 801 WP_223671995.1 hypothetical protein -
KYC43_RS06140 (1245625) 1245625..1246104 - 480 WP_223671996.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
KYC43_RS06145 (1246308) 1246308..1247102 - 795 WP_181588489.1 TraB/GumN family protein -
KYC43_RS06150 (1247235) 1247235..1247537 + 303 WP_000057541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYC43_RS06155 (1247573) 1247573..1247914 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
KYC43_RS06160 (1247972) 1247972..1250476 - 2505 WP_182212212.1 copper-exporting P-type ATPase CopA -
KYC43_RS06165 (1250783) 1250783..1252072 + 1290 WP_148048125.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.37 Da        Isoelectric Point: 10.2638

>T210282 WP_000057541.1 NZ_CP079884:1247235-1247537 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

>T210282 NZ_CP104484:c4773140-4772829 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT210282 WP_000806442.1 NZ_CP079884:1247573-1247914 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp

>AT210282 NZ_CP104484:c4772828-4772538 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A1R1

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References