Detailed information of TA system TA210211

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2069436..2069661
• Replicon: chromosome
• Accession: NZ_CP079838
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA3

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: A0A636EVM3
• Locus tag: JMJ83_RS09830
• Protein ID: WP_001597144.1
• Coordinates: 2069506..2069661 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2069436..2069494 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ83_RS09785	2065034..2065270	+	237	WP_079809900.1	hypothetical protein	-
JMJ83_RS09790	2065235..2065540	-	306	WP_079809899.1	hypothetical protein	-
JMJ83_RS09795	2065707..2066093	-	387	WP_052938955.1	helix-turn-helix domain-containing protein	-
JMJ83_RS09800	2066197..2066457	+	261	WP_072104698.1	YdaS family helix-turn-helix protein	-
JMJ83_RS09805	2066454..2066948	+	495	WP_052938953.1	hypothetical protein	-
JMJ83_RS09810	2066993..2067862	+	870	WP_058111754.1	hypothetical protein	-
JMJ83_RS09815	2067869..2068621	+	753	WP_079809897.1	ATP-binding protein	-
JMJ83_RS09820	2068639..2069034	+	396	WP_047588288.1	DUF977 family protein	-
JMJ83_RS09825	2069031..2069303	+	273	WP_000687976.1	hypothetical protein	-
-	2069436..2069494	-	59	-	-	Antitoxin
JMJ83_RS09830	2069506..2069661	+	156	WP_001597144.1	Hok/Gef family protein	Toxin
JMJ83_RS09835	2069900..2070067	+	168	WP_175441067.1	hypothetical protein	-
JMJ83_RS23980	2070128..2070208	+	81	Protein_1937	hypothetical protein	-
JMJ83_RS09840	2070238..2070675	+	438	WP_000023105.1	recombination protein NinB	-
JMJ83_RS23985	2070672..2070866	+	195	WP_072104694.1	hypothetical protein	-
JMJ83_RS09845	2070863..2071144	+	282	WP_052938933.1	DUF1364 family protein	-
JMJ83_RS09850	2071141..2071677	+	537	WP_052938913.1	DUF1133 family protein	-
JMJ83_RS09855	2072190..2072498	+	309	WP_000177624.1	HP1 family phage holin	-
JMJ83_RS09860	2072476..2073015	+	540	WP_219190831.1	lysozyme	-
JMJ83_RS09865	2073324..2073788	+	465	WP_058215222.1	lysis protein	-
JMJ83_RS09870	2073965..2074198	+	234	WP_016716098.1	DUF826 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2055851..2109489	53638

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5742.91 Da
• Isoelectric Point: 6.1531

>T210211 WP_001597144.1 NZ_CP079838:2069506-2069661 [Salmonella enterica subsp. salamae]
MKQQKAMLIALIVICITVVMAVLVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T210211 NZ_CP104472:1922751-1923128 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT210211 NZ_CP079838:c2069494-2069436 [Salmonella enterica subsp. salamae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A636EVM3

Antitoxin