Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4934146..4934662 | Replicon | chromosome |
Accession | NZ_CP079807 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC02_S465MC |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | KWL80_RS24270 | Protein ID | WP_040216106.1 |
Coordinates | 4934146..4934430 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | KWL80_RS24275 | Protein ID | WP_064162488.1 |
Coordinates | 4934420..4934662 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KWL80_RS24245 (4929563) | 4929563..4929826 | - | 264 | WP_014908078.1 | PTS sugar transporter subunit IIB | - |
KWL80_RS24250 (4929956) | 4929956..4930129 | + | 174 | WP_032425422.1 | hypothetical protein | - |
KWL80_RS24255 (4930132) | 4930132..4930875 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
KWL80_RS24260 (4931232) | 4931232..4933370 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
KWL80_RS24265 (4933678) | 4933678..4934142 | + | 465 | WP_064162487.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
KWL80_RS24270 (4934146) | 4934146..4934430 | - | 285 | WP_040216106.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KWL80_RS24275 (4934420) | 4934420..4934662 | - | 243 | WP_064162488.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
KWL80_RS24280 (4934740) | 4934740..4936650 | - | 1911 | WP_023325426.1 | PRD domain-containing protein | - |
KWL80_RS24285 (4936673) | 4936673..4937827 | - | 1155 | WP_064162489.1 | lactonase family protein | - |
KWL80_RS24290 (4937894) | 4937894..4938634 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11097.94 Da Isoelectric Point: 10.4962
>T210150 WP_040216106.1 NZ_CP079807:c4934430-4934146 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T210150 NZ_CP104442:c1943963-1943856 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9059.57 Da Isoelectric Point: 6.3340
>AT210150 WP_064162488.1 NZ_CP079807:c4934662-4934420 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT210150 NZ_CP104442:1944011-1944077 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|