Detailed information of TA system TA210146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2773646..2775234
• Replicon: chromosome
• Accession: NZ_CP079807
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC02_S465MC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KWL80_RS13715
• Protein ID: WP_064162061.1
• Coordinates: 2773646..2774968 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: KWL80_RS13720
• Protein ID: WP_002904790.1
• Coordinates: 2774968..2775234 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWL80_RS13700 (2768702)	2768702..2771203	+	2502	WP_064162059.1	fimbria/pilus outer membrane usher protein	-
KWL80_RS13705 (2771191)	2771191..2772195	+	1005	WP_064162060.1	fimbrial protein	-
KWL80_RS13710 (2772337)	2772337..2773629	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KWL80_RS13715 (2773646)	2773646..2774968	-	1323	WP_064162061.1	type II toxin-antitoxin system HipA family toxin	Toxin
KWL80_RS13720 (2774968)	2774968..2775234	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KWL80_RS13725 (2775500)	2775500..2775826	-	327	WP_064162062.1	hydroxyisourate hydrolase	-
KWL80_RS13730 (2775823)	2775823..2776323	-	501	WP_064162063.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KWL80_RS13735 (2776301)	2776301..2777680	-	1380	WP_040245186.1	nucleobase:cation symporter-2 family protein	-
KWL80_RS13740 (2778026)	2778026..2779180	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KWL80_RS13745 (2779161)	2779161..2780084	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49155.46 Da
• Isoelectric Point: 7.5357

>T210146 WP_064162061.1 NZ_CP079807:c2774968-2773646 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T210146 NZ_CP104442:c932471-932193 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT210146 WP_002904790.1 NZ_CP079807:c2775234-2774968 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT210146 NZ_CP104442:c932734-932474 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8