Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4259287..4259980 Replicon chromosome
Accession NZ_CP079772
Organism Escherichia coli strain GS04

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KYX57_RS20840 Protein ID WP_000415584.1
Coordinates 4259287..4259583 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KYX57_RS20845 Protein ID WP_000650107.1
Coordinates 4259585..4259980 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX57_RS20805 (4254375) 4254375..4254689 - 315 WP_000958598.1 putative quinol monooxygenase -
KYX57_RS20810 (4254720) 4254720..4255301 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KYX57_RS20815 (4255620) 4255620..4255952 + 333 WP_000917684.1 DUF2645 family protein -
KYX57_RS20820 (4255998) 4255998..4257347 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KYX57_RS20825 (4257344) 4257344..4258003 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KYX57_RS20830 (4258155) 4258155..4258547 + 393 WP_148116247.1 OB fold stress tolerance protein YgiW -
KYX57_RS20835 (4258600) 4258600..4259082 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KYX57_RS20840 (4259287) 4259287..4259583 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KYX57_RS20845 (4259585) 4259585..4259980 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KYX57_RS20850 (4260113) 4260113..4261720 + 1608 WP_148116248.1 ABC transporter substrate-binding protein -
KYX57_RS20855 (4261858) 4261858..4264116 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210035 WP_000415584.1 NZ_CP079772:4259287-4259583 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210035 NZ_CP104371:c2016428-2016021 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210035 WP_000650107.1 NZ_CP079772:4259585-4259980 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210035 NZ_CP104371:c2016675-2016409 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References