Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2044410..2045631 Replicon chromosome
Accession NZ_CP079757
Organism Pseudomonas aeruginosa strain PA0200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KXJ64_RS09710 Protein ID WP_003114949.1
Coordinates 2044410..2044988 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KXJ64_RS09715 Protein ID WP_003088112.1
Coordinates 2045077..2045631 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ64_RS09695 (KXJ64_09665) 2039687..2040964 + 1278 WP_003102743.1 TolC family protein -
KXJ64_RS09700 (KXJ64_09670) 2040954..2043125 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
KXJ64_RS09705 (KXJ64_09675) 2043115..2044302 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KXJ64_RS09710 (KXJ64_09680) 2044410..2044988 - 579 WP_003114949.1 HD domain-containing protein Toxin
KXJ64_RS09715 (KXJ64_09685) 2045077..2045631 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KXJ64_RS09720 (KXJ64_09690) 2045789..2047984 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KXJ64_RS09725 (KXJ64_09695) 2047989..2048450 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
KXJ64_RS09730 (KXJ64_09700) 2048781..2049104 + 324 WP_003102734.1 multidrug efflux SMR transporter -
KXJ64_RS09735 (KXJ64_09705) 2049117..2049515 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KXJ64_RS09740 (KXJ64_09710) 2049512..2050063 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T209922 WP_003114949.1 NZ_CP079757:c2044988-2044410 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T209922 NZ_CP104339:c53158-52871 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT209922 WP_003088112.1 NZ_CP079757:c2045631-2045077 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT209922 NZ_CP104339:c52884-52570 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References