Detailed information of TA system TA020988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4081634..4082292
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GLL_RS19970
• Protein ID: WP_197530051.1
• Coordinates: 4081906..4082292 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q7NEK5
• Locus tag: GLL_RS19965
• Protein ID: WP_011143862.1
• Coordinates: 4081634..4081882 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS19945	4076846..4079074	-	2229	WP_197530050.1	S9 family peptidase	-
GLL_RS19950	4079150..4079548	-	399	WP_011143860.1	hypothetical protein	-
GLL_RS19955	4079607..4080218	-	612	WP_011143861.1	DUF938 domain-containing protein	-
GLL_RS19960	4080323..4081291	-	969	WP_164929397.1	hypothetical protein	-
GLL_RS19965	4081634..4081882	+	249	WP_011143862.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GLL_RS19970	4081906..4082292	+	387	WP_197530051.1	type II toxin-antitoxin system VapC family toxin	Toxin
GLL_RS19975	4082299..4083201	-	903	WP_197530204.1	oxygen-dependent coproporphyrinogen oxidase	-
GLL_RS19980	4083210..4084253	-	1044	WP_011143865.1	uroporphyrinogen decarboxylase	-
GLL_RS19985	4084400..4086352	-	1953	WP_011143866.1	alpha-glucan family phosphorylase	-
GLL_RS19990	4086750..4087220	-	471	WP_164929399.1	type II secretion system GspH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4058097..4082292	24195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (15-116)

Antitoxin

• SpoVT-AbrB domain (10-45)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13914.00 Da
• Isoelectric Point: 6.4760

>T20988 WP_197530051.1 NC_005125:4081906-4082292 [Gloeobacter violaceus PCC 7421]
VIAVIKNAPPGVRIRLREVLAAEASVAISTIALFELWYGVAKSARRKENTERLRAFLSGSVEVFAFEEEDAVRAGELRAV
LHAAGTPIGPYDLLMAAQAQRHSATLVTANVVEFARVPGLIWEDWTGT

Nucleotide

• Length: 387 bp

>T20988 NC_005125:4081906-4082292 [Gloeobacter violaceus PCC 7421]
GTGATCGCAGTGATCAAAAATGCCCCGCCCGGCGTCCGAATTCGACTACGAGAAGTTCTTGCGGCGGAAGCTTCGGTGGC
AATTTCCACTATTGCCTTGTTCGAGCTTTGGTATGGCGTGGCTAAGAGTGCACGGCGCAAAGAAAATACCGAACGCCTGC
GCGCCTTTCTATCCGGCAGTGTGGAAGTGTTCGCCTTTGAGGAGGAGGATGCTGTCCGTGCGGGCGAATTGCGCGCTGTA
TTACACGCGGCCGGCACCCCTATCGGTCCTTATGACCTGCTGATGGCTGCCCAGGCGCAGCGGCACAGCGCAACACTTGT
AACCGCCAACGTTGTGGAGTTTGCCCGCGTACCCGGTCTCATCTGGGAGGACTGGACCGGCACCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9316.77 Da
• Isoelectric Point: 5.8065

>AT20988 WP_011143862.1 NC_005125:4081634-4081882 [Gloeobacter violaceus PCC 7421]
MSDSGVAKIFWHGRSQAVRLPMAFRLPGDRVRVRRVGDGILLEPIVTDIDAWFGAMDRFADVPFMEEGRQQPPMPEAKTL
FE

Nucleotide

• Length: 249 bp

>AT20988 NC_005125:4081634-4081882 [Gloeobacter violaceus PCC 7421]
ATGTCCGACTCTGGTGTTGCCAAAATTTTCTGGCATGGGCGCAGCCAGGCTGTGCGTCTTCCCATGGCTTTTCGCCTGCC
TGGAGACCGAGTGCGGGTGCGTAGAGTCGGAGATGGCATCCTGTTGGAGCCTATCGTTACCGACATCGATGCGTGGTTTG
GTGCAATGGATCGTTTTGCCGATGTCCCTTTTATGGAAGAGGGTCGTCAGCAGCCGCCTATGCCCGAGGCAAAGACTTTG
TTTGAGTGA

Structures

Antitoxin

• AlphaFold DB: Q7NEK5