Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 5686583..5687102 | Replicon | chromosome |
| Accession | NZ_CP079716 | ||
| Organism | Pseudomonas amygdali strain HS1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7Z6UJD9 |
| Locus tag | KXJ79_RS25000 | Protein ID | WP_010434526.1 |
| Coordinates | 5686583..5686873 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A7Z6UGD7 |
| Locus tag | KXJ79_RS25005 | Protein ID | WP_058400041.1 |
| Coordinates | 5686863..5687102 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KXJ79_RS24965 (KXJ79_24960) | 5681747..5682034 | + | 288 | WP_257605734.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KXJ79_RS24970 (KXJ79_24965) | 5682010..5682372 | + | 363 | WP_219170606.1 | putative addiction module antidote protein | - |
| KXJ79_RS24975 (KXJ79_24970) | 5682429..5683043 | - | 615 | WP_219170607.1 | histidine phosphatase family protein | - |
| KXJ79_RS24980 (KXJ79_24975) | 5683148..5683489 | - | 342 | WP_058400046.1 | DUF5713 family protein | - |
| KXJ79_RS24985 (KXJ79_24980) | 5683953..5684456 | + | 504 | WP_058400045.1 | type VI secretion system tube protein Hcp | - |
| KXJ79_RS24990 (KXJ79_24985) | 5684901..5685323 | + | 423 | WP_219170608.1 | DUF1493 family protein | - |
| KXJ79_RS24995 (KXJ79_24990) | 5685629..5686366 | + | 738 | WP_058400043.1 | hypothetical protein | - |
| KXJ79_RS26375 | 5686377..5686508 | - | 132 | Protein_4931 | GNAT family N-acetyltransferase | - |
| KXJ79_RS25000 (KXJ79_24995) | 5686583..5686873 | - | 291 | WP_010434526.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KXJ79_RS25005 (KXJ79_25000) | 5686863..5687102 | - | 240 | WP_058400041.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KXJ79_RS25010 (KXJ79_25005) | 5687266..5687739 | - | 474 | WP_058400040.1 | GNAT family N-acetyltransferase | - |
| KXJ79_RS25015 (KXJ79_25010) | 5687838..5689289 | - | 1452 | WP_219170609.1 | putative DNA binding domain-containing protein | - |
| KXJ79_RS25020 (KXJ79_25015) | 5689282..5689914 | - | 633 | WP_058400038.1 | DUF4062 domain-containing protein | - |
| KXJ79_RS25025 (KXJ79_25020) | 5690072..5690620 | - | 549 | WP_122259193.1 | GNAT family N-acetyltransferase | - |
| KXJ79_RS25030 (KXJ79_25025) | 5690780..5691274 | + | 495 | WP_058400036.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11187.03 Da Isoelectric Point: 10.0984
>T209779 WP_010434526.1 NZ_CP079716:c5686873-5686583 [Pseudomonas amygdali]
MTYNLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQEVVVFVVAVDK
REREEVYRKAADRLGG
MTYNLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQEVVVFVVAVDK
REREEVYRKAADRLGG
Download Length: 291 bp
>T209779 NZ_CP104309:c653030-652566 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8937.31 Da Isoelectric Point: 4.6017
>AT209779 WP_058400041.1 NZ_CP079716:c5687102-5686863 [Pseudomonas amygdali]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLLTEEDEALLATVRERLAAPQRVKVSLDDL
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLLTEEDEALLATVRERLAAPQRVKVSLDDL
Download Length: 240 bp
>AT209779 NZ_CP104309:c653365-653030 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z6UJD9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z6UGD7 |