Detailed information of TA system TA209711

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4812340..4812856
• Replicon: chromosome
• Accession: NZ_CP079683
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC30_AI1547MPCH

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KW563_RS23475
• Protein ID: WP_040216106.1
• Coordinates: 4812340..4812624 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KW563_RS23480
• Protein ID: WP_064162488.1
• Coordinates: 4812614..4812856 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW563_RS23450 (4807757)	4807757..4808020	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
KW563_RS23455 (4808150)	4808150..4808323	+	174	WP_032425422.1	hypothetical protein	-
KW563_RS23460 (4808326)	4808326..4809069	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KW563_RS23465 (4809426)	4809426..4811564	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
KW563_RS23470 (4811872)	4811872..4812336	+	465	WP_064162487.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KW563_RS23475 (4812340)	4812340..4812624	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KW563_RS23480 (4812614)	4812614..4812856	-	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KW563_RS23485 (4812934)	4812934..4814844	-	1911	WP_023325426.1	PRD domain-containing protein	-
KW563_RS23490 (4814867)	4814867..4816021	-	1155	WP_064162489.1	lactonase family protein	-
KW563_RS23495 (4816088)	4816088..4816828	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T209711 WP_040216106.1 NZ_CP079683:c4812624-4812340 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T209711 NZ_CP104284:1661043-1661564 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT209711 WP_064162488.1 NZ_CP079683:c4812856-4812614 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT209711 NZ_CP104284:1660767-1661036 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA