Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 3352225..3353813 | Replicon | chromosome |
| Accession | NZ_CP079645 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC24_S468MC | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | KW559_RS16425 | Protein ID | WP_064162061.1 |
| Coordinates | 3352491..3353813 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | KW559_RS16420 | Protein ID | WP_002904790.1 |
| Coordinates | 3352225..3352491 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW559_RS16395 (3347375) | 3347375..3348298 | + | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
| KW559_RS16400 (3348279) | 3348279..3349433 | - | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| KW559_RS16405 (3349779) | 3349779..3351158 | + | 1380 | WP_040245186.1 | nucleobase:cation symporter-2 family protein | - |
| KW559_RS16410 (3351136) | 3351136..3351636 | + | 501 | WP_064162063.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| KW559_RS16415 (3351633) | 3351633..3351959 | + | 327 | WP_064162062.1 | hydroxyisourate hydrolase | - |
| KW559_RS16420 (3352225) | 3352225..3352491 | + | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| KW559_RS16425 (3352491) | 3352491..3353813 | + | 1323 | WP_064162061.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KW559_RS16430 (3353830) | 3353830..3355122 | - | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| KW559_RS16435 (3355264) | 3355264..3356268 | - | 1005 | WP_064162060.1 | fimbrial protein | - |
| KW559_RS16440 (3356256) | 3356256..3358757 | - | 2502 | WP_064162059.1 | fimbria/pilus outer membrane usher protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49155.46 Da Isoelectric Point: 7.5357
>T209623 WP_064162061.1 NZ_CP079645:3352491-3353813 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T209623 NZ_CP104174:c3412050-3411643 [Bradyrhizobium sp. CB1015]
ATGACGAAATGGCTTCTCGACACCAACGCCGTCATCGCACTCGTCACGCGCCGGTCGGAGCCTCTCCTGCGCCGGGTTGA
ATCCACCGAGCCCGGTGCGCTCGCAATCTCATCCATCGTTGCCCACGAACTCTACTTCGGCGCCTATCGCAGCCAGAAGA
TCGAATTCAACCTGGAAACGCTTCGCCTTGTCTTTACCGATCTCGACATCGTCGACCTCGACCAAGAGGACGCGCGAGCC
GCCGGCGAGATACGGGCGGAGCTGGCGCGGCGCAGCACGCCGATCGGCCCCTACGATCTCCTGATCGCCGGTCAGGCGAT
CGCGCGCGGCCTGCCGCTCGTCAGCAACAACACCGCCGAATTCCAGCGCATTGCCGGATTGCGGCTGGAGGACTGGACGA
GGGATTGA
ATGACGAAATGGCTTCTCGACACCAACGCCGTCATCGCACTCGTCACGCGCCGGTCGGAGCCTCTCCTGCGCCGGGTTGA
ATCCACCGAGCCCGGTGCGCTCGCAATCTCATCCATCGTTGCCCACGAACTCTACTTCGGCGCCTATCGCAGCCAGAAGA
TCGAATTCAACCTGGAAACGCTTCGCCTTGTCTTTACCGATCTCGACATCGTCGACCTCGACCAAGAGGACGCGCGAGCC
GCCGGCGAGATACGGGCGGAGCTGGCGCGGCGCAGCACGCCGATCGGCCCCTACGATCTCCTGATCGCCGGTCAGGCGAT
CGCGCGCGGCCTGCCGCTCGTCAGCAACAACACCGCCGAATTCCAGCGCATTGCCGGATTGCGGCTGGAGGACTGGACGA
GGGATTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT209623 WP_002904790.1 NZ_CP079645:3352225-3352491 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT209623 NZ_CP104174:c3412307-3412047 [Bradyrhizobium sp. CB1015]
ATGCCCCACATCGCCAAAGTGTTCAAATCTGGTAACTCCCAGGCCGTCCGGCTGCCGAAGGATTTTCGTTTCTCCGTGGA
GGAAGTCGAGGTTTCCCGCGAGGGCGATGCTGTGATCCTGCGCCCAAGGCGGAGCGCGGCCGGCCCGTGGGCATCGCTTC
GCGCGGCCATCGCACGCGGCTTCAGCCCGGACTTCATGGCTGACGGCCGGGAGCAACCTGAAGAGCAGACGCGTCCCGAT
CTGGACCGGGCGTTTCGATGA
ATGCCCCACATCGCCAAAGTGTTCAAATCTGGTAACTCCCAGGCCGTCCGGCTGCCGAAGGATTTTCGTTTCTCCGTGGA
GGAAGTCGAGGTTTCCCGCGAGGGCGATGCTGTGATCCTGCGCCCAAGGCGGAGCGCGGCCGGCCCGTGGGCATCGCTTC
GCGCGGCCATCGCACGCGGCTTCAGCCCGGACTTCATGGCTGACGGCCGGGAGCAACCTGAAGAGCAGACGCGTCCCGAT
CTGGACCGGGCGTTTCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|