Detailed information of TA system TA209536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2908825..2910413
• Replicon: chromosome
• Accession: NZ_CP079624
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC17_CMC307PC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KW552_RS14550
• Protein ID: WP_004179815.1
• Coordinates: 2908825..2910147 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KW552_RS14555
• Protein ID: WP_004176198.1
• Coordinates: 2910147..2910413 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW552_RS14535 (2903881)	2903881..2906382	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
KW552_RS14540 (2906370)	2906370..2907374	+	1005	WP_004179822.1	fimbrial protein	-
KW552_RS14545 (2907516)	2907516..2908808	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KW552_RS14550 (2908825)	2908825..2910147	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KW552_RS14555 (2910147)	2910147..2910413	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KW552_RS14560 (2910679)	2910679..2911005	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KW552_RS14565 (2911002)	2911002..2911502	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KW552_RS14570 (2911480)	2911480..2912859	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KW552_RS14575 (2913204)	2913204..2914358	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KW552_RS14580 (2914339)	2914339..2915262	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209536 WP_004179815.1 NZ_CP079624:c2910147-2908825 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209536 NZ_CP104126:c432557-432303 [Sinorhizobium sp. M103]
TTGGAGCGATGCCGGCGGTTCCTGGCCACTAAGGCCCCGGAAGCTGCCAGACGGGCCGGCCAGGCCATCGAGCGGCAATT
CCTGCTGCTGGAGACGGCGCCCGACATTGGCCGGCCGTTCTCCGAAGCGCCTGAGCTGCGTGAGCTCGTGATTGCCTTCG
GGGACTCCGGCTATGTGGCCCTGTACCATCACCAGCCGGCCGACGATGCGGTGTATGTTCTTGCCTTCCGGCACCAGAAA
GAAGCGGGCTACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209536 WP_004176198.1 NZ_CP079624:c2910413-2910147 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209536 NZ_CP104126:c432856-432584 [Sinorhizobium sp. M103]
ATGGCAACGTCTCTCAAGATCGACGACACACTGAAAAGTCGCGTACAGCAGCTCGCCAGTCAGCGCCGCCGCTCGCCCCA
CTGGATCATGCTCGAAGCGATCCAACAGTACGTTGAGCGCGAGGAAGCACGCGAGAGCTTCAAGCAGGAGGCCTTGGCGT
CCTGGGCCGCGTACAAGGAAACCGGCCGCCACCTCACCGGCGAAGAAGTCCGCACCTGGTTGACTACCTGGGGCACCGAT
GACGAAAAGCCGGTGCCAGAGTGCCACAAGTAA