Detailed information of TA system TA209263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4259510..4260096
• Replicon: chromosome
• Accession: NZ_CP079120
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC03_AI1235PC

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: KWV87_RS20890
• Protein ID: WP_002920800.1
• Coordinates: 4259510..4259878 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: W9B1V1
• Locus tag: KWV87_RS20895
• Protein ID: WP_004174006.1
• Coordinates: 4259875..4260096 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWV87_RS20870 (4255013)	4255013..4256083	-	1071	WP_043906884.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
KWV87_RS20875 (4256085)	4256085..4256930	-	846	WP_004181473.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
KWV87_RS20880 (4256927)	4256927..4257814	-	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
KWV87_RS20885 (4257921)	4257921..4259237	-	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
KWV87_RS20890 (4259510)	4259510..4259878	-	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KWV87_RS20895 (4259875)	4259875..4260096	-	222	WP_004174006.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KWV87_RS20900 (4260260)	4260260..4260973	-	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
KWV87_RS20905 (4260975)	4260975..4261742	-	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
KWV87_RS20910 (4261739)	4261739..4263016	-	1278	WP_004174005.1	branched chain amino acid ABC transporter permease LivM	-
KWV87_RS20915 (4263013)	4263013..4263939	-	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4254276..4265110	10834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T209263 WP_002920800.1 NZ_CP079120:c4259878-4259510 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T209263 NZ_CP103995:519877-520227 [Bacillus subtilis]
TTGATTGTGAAACGAGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.15 Da
• Isoelectric Point: 4.7769

>AT209263 WP_004174006.1 NZ_CP079120:c4260096-4259875 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT209263 NZ_CP103995:519591-519872 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1

Antitoxin

• AlphaFold DB: A0A5E5YJY7