Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3297953..3298614 Replicon chromosome
Accession NZ_CP078096
Organism Geomonas subterranea strain RG3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KP002_RS14315 Protein ID WP_217286397.1
Coordinates 3297953..3298354 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KP002_RS14320 Protein ID WP_217286396.1
Coordinates 3298369..3298614 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP002_RS14305 (KP002_14305) 3295272..3296285 - 1014 WP_217286399.1 amidohydrolase family protein -
KP002_RS14310 (KP002_14310) 3296473..3297945 + 1473 WP_217286398.1 sigma 54-interacting transcriptional regulator -
KP002_RS14315 (KP002_14315) 3297953..3298354 - 402 WP_217286397.1 type II toxin-antitoxin system VapC family toxin Toxin
KP002_RS14320 (KP002_14320) 3298369..3298614 - 246 WP_217286396.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KP002_RS14325 (KP002_14325) 3298899..3299207 + 309 WP_217286395.1 TRL-like family protein -
KP002_RS14330 (KP002_14330) 3299309..3300256 - 948 WP_217286394.1 D-2-hydroxyacid dehydrogenase -
KP002_RS14335 (KP002_14335) 3300256..3301053 - 798 WP_217286393.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(12-57)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14472.65 Da        Isoelectric Point: 4.9104

>T208985 WP_217286397.1 NZ_CP078096:c3298354-3297953 [Geomonas subterranea]
MYLLDTSVFSDLIKRPGGPVTRRIASVGEDAICTSIVVACELRFGAEKKRSTSLTAKVEQIIANIEVLSLDVDADAHYAT
IRNDLELRGETIGPNDLLIAAHARSLGLILVTDNVREFARVPGLSVENWLTLP

Download         Length: 402 bp

>T208985 NZ_CP103771:c2233165-2232881 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9198.42 Da        Isoelectric Point: 4.6882

>AT208985 WP_217286396.1 NZ_CP078096:c3298614-3298369 [Geomonas subterranea]
MSEFTERHVRLFKNGRNQAIRIPREFELPGDEAIIHKEGNRLIIEPAKKKSLLGLLSTWGPSGEEFPDVDEGLAQLDDVE
L

Download         Length: 246 bp

>AT208985 NZ_CP103771:c2233403-2233155 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References