Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2833960..2834601 Replicon chromosome
Accession NZ_CP078071
Organism Burkholderia sp. EMB26

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KU887_RS29525 Protein ID WP_258256615.1
Coordinates 2834263..2834601 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KU887_RS29520 Protein ID WP_006490972.1
Coordinates 2833960..2834259 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU887_RS29495 (KU887_29350) 2829180..2830451 + 1272 WP_077190813.1 anthranilate 1,2-dioxygenase large subunit AndAc -
KU887_RS29500 (KU887_29355) 2830467..2830943 + 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KU887_RS29505 (KU887_29360) 2830979..2831305 + 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KU887_RS29510 (KU887_29365) 2831295..2832515 + 1221 WP_258256610.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KU887_RS29515 (KU887_29370) 2832625..2833911 + 1287 WP_125332129.1 DUF445 domain-containing protein -
KU887_RS29520 (KU887_29375) 2833960..2834259 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
KU887_RS29525 (KU887_29380) 2834263..2834601 - 339 WP_258256615.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU887_RS29530 (KU887_29385) 2834969..2836609 + 1641 WP_006490980.1 acetolactate synthase large subunit -
KU887_RS29535 (KU887_29390) 2836638..2838071 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(17-107)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12557.45 Da        Isoelectric Point: 7.8853

>T208972 WP_258256615.1 NZ_CP078071:c2834601-2834263 [Burkholderia sp. EMB26]
MVDTLQCMPYSPPSFGIRTIDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGNWKSAGSPVVEMRIDHGPGYRVYDVRRG
TIWVILLCGGDQSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T208972 NZ_CP103764:222-602 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCAGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT208972 WP_006490972.1 NZ_CP078071:c2834259-2833960 [Burkholderia sp. EMB26]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT208972 NZ_CP103764:1-222 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References