Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7392..8043 Replicon plasmid pAJ_068-3
Accession NZ_CP078044
Organism Acinetobacter junii strain AJ_068

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EGT68_RS16510 Protein ID WP_125272718.1
Coordinates 7392..7748 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGT68_RS16515 Protein ID WP_005804939.1
Coordinates 7741..8043 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT68_RS16490 (EGT68_016490) 2831..3472 + 642 WP_032072990.1 AAA family ATPase -
EGT68_RS16495 (EGT68_016495) 3472..3807 + 336 WP_032072989.1 hypothetical protein -
EGT68_RS16500 (EGT68_016500) 3965..4264 + 300 WP_032072988.1 hypothetical protein -
EGT68_RS16505 (EGT68_016505) 4496..6580 - 2085 WP_125268827.1 catalase -
EGT68_RS16510 (EGT68_016510) 7392..7748 + 357 WP_125272718.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGT68_RS16515 (EGT68_016515) 7741..8043 + 303 WP_005804939.1 XRE family transcriptional regulator Antitoxin
EGT68_RS16520 (EGT68_016520) 8116..8574 - 459 WP_125272719.1 hypothetical protein -
EGT68_RS16525 (EGT68_016525) 9017..9172 + 156 WP_218999233.1 hypothetical protein -
EGT68_RS16530 (EGT68_016530) 9238..9531 + 294 WP_000930834.1 helix-turn-helix transcriptional regulator -
EGT68_RS16535 (EGT68_016535) 9521..10423 + 903 WP_125272720.1 reverse transcriptase family protein -
EGT68_RS16540 (EGT68_016540) 10555..11409 + 855 WP_125272721.1 DUF4062 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19316 19316
- flank IS/Tn - - 11752..13089 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.39 Da        Isoelectric Point: 5.7104

>T208955 WP_125272718.1 NZ_CP078044:7392-7748 [Acinetobacter junii]
MWTVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFNNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYTEMLAIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T208955 NZ_CP103762:c2618409-2618233 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11213.98 Da        Isoelectric Point: 5.7440

>AT208955 WP_005804939.1 NZ_CP078044:7741-8043 [Acinetobacter junii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT208955 NZ_CP103762:c2618187-2617771 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References