Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1746295..1747931 Replicon chromosome
Accession NZ_CP078018
Organism Acinetobacter junii strain AJ_351

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EGT69_RS08110 Protein ID WP_087540912.1
Coordinates 1746295..1747626 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EGT69_RS08115 Protein ID WP_087540911.1
Coordinates 1747623..1747931 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT69_RS08085 (EGT69_008085) 1741692..1742687 + 996 WP_004911105.1 DUF1852 domain-containing protein -
EGT69_RS08090 (EGT69_008090) 1742711..1743739 + 1029 WP_087540915.1 methionine synthase -
EGT69_RS08095 (EGT69_008095) 1743926..1744420 + 495 WP_004954405.1 flavin reductase -
EGT69_RS08100 (EGT69_008100) 1744462..1745259 + 798 WP_039907982.1 sulfite exporter TauE/SafE family protein -
EGT69_RS08105 (EGT69_008105) 1745319..1746017 - 699 WP_087540914.1 DUF1826 domain-containing protein -
EGT69_RS08110 (EGT69_008110) 1746295..1747626 + 1332 WP_087540912.1 HipA domain-containing protein Toxin
EGT69_RS08115 (EGT69_008115) 1747623..1747931 + 309 WP_087540911.1 helix-turn-helix domain-containing protein Antitoxin
EGT69_RS08120 (EGT69_008120) 1748009..1748140 - 132 Protein_1580 VF530 family DNA-binding protein -
EGT69_RS08125 (EGT69_008125) 1748160..1749086 + 927 Protein_1581 IS3 family transposase -
EGT69_RS08130 (EGT69_008130) 1749364..1751661 - 2298 WP_087540909.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1489463..1857945 368482
- flank IS/Tn - - 1748232..1749086 854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-363)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50699.39 Da        Isoelectric Point: 4.8438

>T208908 WP_087540912.1 NZ_CP078018:1746295-1747626 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYELEYAIHNLDKRDEHACGLSLPVQLLIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRYGLESVYSVLNKASGSHLNHFEVIENLCNLLISIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYQWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEIPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T208908 NZ_CP103755:c3987601-3986681 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11722.67 Da        Isoelectric Point: 9.9970

>AT208908 WP_087540911.1 NZ_CP078018:1747623-1747931 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILSMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT208908 NZ_CP103755:c3988370-3987588 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References