Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143246..143751 Replicon chromosome
Accession NZ_CP077985
Organism Pseudomonas aeruginosa strain ZPPH2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag KUU77_RS00660 Protein ID WP_003083773.1
Coordinates 143246..143527 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KUU77_RS00665 Protein ID WP_003083775.1
Coordinates 143524..143751 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU77_RS00635 (KUU77_00635) 138497..139846 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KUU77_RS00640 (KUU77_00640) 139895..140581 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KUU77_RS00645 (KUU77_00645) 140682..141416 + 735 WP_003117208.1 GntR family transcriptional regulator -
KUU77_RS00650 (KUU77_00650) 141596..142006 + 411 WP_003101225.1 aegerolysin family protein -
KUU77_RS00655 (KUU77_00655) 142038..142946 - 909 WP_016561475.1 LysR family transcriptional regulator -
KUU77_RS00660 (KUU77_00660) 143246..143527 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
KUU77_RS00665 (KUU77_00665) 143524..143751 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KUU77_RS00670 (KUU77_00670) 143927..144547 - 621 WP_003101226.1 hypothetical protein -
KUU77_RS00675 (KUU77_00675) 144648..145148 + 501 WP_003101228.1 LEA type 2 family protein -
KUU77_RS00680 (KUU77_00680) 145221..145562 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KUU77_RS00685 (KUU77_00685) 145644..147071 - 1428 WP_003083784.1 GABA permease -
KUU77_RS00690 (KUU77_00690) 147240..148733 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T208804 WP_003083773.1 NZ_CP077985:c143527-143246 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T208804 NZ_CP103739:526592-526765 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT208804 WP_003083775.1 NZ_CP077985:c143751-143524 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT208804 NZ_CP103739:526268-526564 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References