208769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2689707..2690374 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag KTJ86_RS13125 Protein ID WP_001094400.1
Coordinates 2690045..2690374 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag KTJ86_RS13120 Protein ID WP_000072690.1
Coordinates 2689707..2690024 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS13090 (2684759) 2684759..2685768 - 1010 Protein_2562 arsenic transporter -
KTJ86_RS13095 (2685910) 2685910..2687613 + 1704 WP_001698958.1 protein YfjW -
KTJ86_RS13100 (2688185) 2688185..2688408 + 224 Protein_2564 DUF905 domain-containing protein -
KTJ86_RS13105 (2688511) 2688511..2688969 + 459 WP_000211841.1 antirestriction protein -
KTJ86_RS13110 (2688978) 2688978..2689460 + 483 WP_001407480.1 RadC family protein -
KTJ86_RS13115 (2689469) 2689469..2689669 + 201 WP_001395452.1 DUF987 domain-containing protein -
KTJ86_RS13120 (2689707) 2689707..2690024 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KTJ86_RS13125 (2690045) 2690045..2690374 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
KTJ86_RS13130 (2690738) 2690738..2695318 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T208769 WP_001094400.1 NZ_CP077969:2690045-2690374 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T208769 NZ_CP103727:1856903-1857005 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT208769 WP_000072690.1 NZ_CP077969:2689707-2690024 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT208769 NZ_CP103727:c1857012-1856867 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References