Detailed information of TA system TA208710

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1576167..1576746
• Replicon: chromosome
• Accession: NZ_CP077936
• Organism: Staphylococcus aureus strain 319

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KU496_RS07555
• Protein ID: WP_001025401.1
• Coordinates: 1576501..1576746 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1576167..1576532 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU496_RS07515 (1572910)	1572910..1573467	-	558	WP_000645048.1	DUF2815 family protein	-
KU496_RS07520 (1573493)	1573493..1574659	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
KU496_RS07525 (1574656)	1574656..1575018	-	363	WP_000985972.1	hypothetical protein	-
KU496_RS07530 (1575033)	1575033..1575356	-	324	WP_031822699.1	hypothetical protein	-
KU496_RS07535 (1575435)	1575435..1575596	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
KU496_RS07540 (1575609)	1575609..1575872	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
KU496_RS07545 (1575897)	1575897..1576112	-	216	WP_001097552.1	hypothetical protein	-
KU496_RS07550 (1576167)	1576167..1576532	+	366	WP_001128433.1	hypothetical protein	Antitoxin
KU496_RS07555 (1576501)	1576501..1576746	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KU496_RS07560 (1576813)	1576813..1577193	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
KU496_RS07565 (1577180)	1577180..1577377	-	198	WP_001148860.1	hypothetical protein	-
KU496_RS07570 (1577447)	1577447..1577659	+	213	WP_000362644.1	hypothetical protein	-
KU496_RS07575 (1577700)	1577700..1577849	-	150	WP_000771849.1	hypothetical protein	-
KU496_RS07580 (1577864)	1577864..1578307	-	444	WP_000435357.1	hypothetical protein	-
KU496_RS07585 (1578355)	1578355..1578567	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
KU496_RS07590 (1578719)	1578719..1579450	+	732	WP_000511090.1	XRE family transcriptional regulator	-
KU496_RS07595 (1579521)	1579521..1579703	+	183	WP_000705240.1	hypothetical protein	-
KU496_RS07600 (1579740)	1579740..1579886	+	147	WP_001795334.1	hypothetical protein	-
KU496_RS07605 (1579883)	1579883..1580497	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1535650..1599478	63828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T208710 WP_001025401.1 NZ_CP077936:c1576746-1576501 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T208710 NZ_CP103712:79122-79427 [Escherichia coli O25b:H4-ST131]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT208710 NZ_CP077936:1576167-1576532 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin