Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3506840..3507674 Replicon chromosome
Accession NC_004431
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag C_RS17440 Protein ID WP_000854688.1
Coordinates 3507297..3507674 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag C_RS17435 Protein ID WP_001285596.1
Coordinates 3506840..3507220 (+) Length 127 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C_RS17400 3503125..3503580 + 456 WP_000581502.1 hypothetical protein -
C_RS17405 3503659..3503892 + 234 WP_001119727.1 DUF905 family protein -
C_RS17410 3503993..3504811 + 819 WP_001234616.1 DUF945 domain-containing protein -
C_RS17415 3504866..3505351 + 486 WP_000849564.1 antirestriction protein -
C_RS17420 3505367..3505843 + 477 WP_001186726.1 RadC family protein -
C_RS17425 3505906..3506127 + 222 WP_000692329.1 DUF987 domain-containing protein -
C_RS28815 3506146..3506790 + 645 WP_000094917.1 hypothetical protein -
C_RS17435 3506840..3507220 + 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C_RS17440 3507297..3507674 + 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
C_RS17445 3507671..3508159 + 489 WP_000761701.1 hypothetical protein -
C_RS17450 3508176..3508373 + 198 WP_000839260.1 DUF957 domain-containing protein -
C_RS17455 3508458..3509303 + 846 WP_001280441.1 DUF4942 domain-containing protein -
C_RS17460 3509372..3509767 + 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
C_RS17465 3509760..3510694 + 935 Protein_3319 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
C_RS29665 3511126..3511281 + 156 WP_000729639.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM 3506840..3531002 24162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T20833 WP_000854688.1 NC_004431:3507297-3507674 [Escherichia coli CFT073]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T20833 NC_004431:3507297-3507674 [Escherichia coli CFT073]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT20833 WP_001285596.1 NC_004431:3506840-3507220 [Escherichia coli CFT073]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT20833 NC_004431:3506840-3507220 [Escherichia coli CFT073]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0


Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References