Detailed information of TA system TA208058

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449138..449791
• Replicon: chromosome
• Accession: NZ_CP077837
• Organism: Acinetobacter baumannii strain DETAB-E159

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KU204_RS02190
• Protein ID: WP_000607077.1
• Coordinates: 449402..449791 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KU204_RS02185
• Protein ID: WP_001288210.1
• Coordinates: 449138..449395 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU204_RS02165 (KU204_02165)	444654..445661	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KU204_RS02170 (KU204_02170)	445680..446057	+	378	WP_001216380.1	50S ribosomal protein L17	-
KU204_RS02175 (KU204_02175)	446239..447729	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KU204_RS02180 (KU204_02180)	447778..448950	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KU204_RS02185 (KU204_02185)	449138..449395	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KU204_RS02190 (KU204_02190)	449402..449791	+	390	WP_000607077.1	membrane protein	Toxin
KU204_RS02195 (KU204_02195)	450561..451646	+	1086	WP_000049106.1	hypothetical protein	-
KU204_RS02200 (KU204_02200)	451724..452290	+	567	WP_000651538.1	rhombosortase	-
KU204_RS02205 (KU204_02205)	452478..454673	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T208058 WP_000607077.1 NZ_CP077837:449402-449791 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T208058 NZ_CP103561:53928-54410 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT208058 WP_001288210.1 NZ_CP077837:449138-449395 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT208058 NZ_CP103561:53674-53940 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7