Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 37728..38386 Replicon plasmid pDETAB7d
Accession NZ_CP077833
Organism Acinetobacter baumannii strain DETAB-P43

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU224_RS19375 Protein ID WP_000312250.1
Coordinates 38027..38386 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU224_RS19370 Protein ID WP_001096429.1
Coordinates 37728..38027 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU224_RS19325 (KU224_19255) 32761..33018 + 258 WP_000834292.1 hypothetical protein -
KU224_RS19330 (KU224_19260) 33023..33595 + 573 WP_038345812.1 hypothetical protein -
KU224_RS19335 (KU224_19265) 33571..33750 + 180 WP_002081921.1 hypothetical protein -
KU224_RS19340 (KU224_19270) 33767..34396 + 630 WP_002081923.1 hypothetical protein -
KU224_RS19345 (KU224_19275) 34436..34945 + 510 WP_001043199.1 hypothetical protein -
KU224_RS19350 (KU224_19280) 35026..35580 + 555 WP_038345807.1 hypothetical protein -
KU224_RS19355 (KU224_19285) 35630..36166 + 537 WP_000731981.1 hypothetical protein -
KU224_RS19360 (KU224_19290) 36789..37271 + 483 WP_001052677.1 hypothetical protein -
KU224_RS19365 (KU224_19295) 37364..37627 - 264 WP_000110863.1 hypothetical protein -
KU224_RS19370 (KU224_19300) 37728..38027 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
KU224_RS19375 (KU224_19305) 38027..38386 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU224_RS19380 (KU224_19310) 38587..39153 + 567 WP_000710385.1 hypothetical protein -
KU224_RS19385 (KU224_19315) 39202..39384 + 183 WP_000373385.1 hypothetical protein -
KU224_RS19390 (KU224_19320) 39451..40149 + 699 WP_000873188.1 hypothetical protein -
KU224_RS19395 (KU224_19325) 40288..40671 + 384 WP_000654348.1 hypothetical protein -
KU224_RS19400 (KU224_19330) 40738..41496 + 759 WP_001053128.1 hypothetical protein -
KU224_RS19405 (KU224_19335) 41548..41883 + 336 WP_000653925.1 hypothetical protein -
KU224_RS19410 (KU224_19340) 42750..43064 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..84262 84262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T208053 WP_000312250.1 NZ_CP077833:c38386-38027 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T208053 NZ_CP103560:c4718303-4717770 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT208053 WP_001096429.1 NZ_CP077833:c38027-37728 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT208053 NZ_CP103560:c4718580-4718314 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References