Detailed information of TA system TA208046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1552289..1552968
• Replicon: chromosome
• Accession: NZ_CP077828
• Organism: Acinetobacter baumannii strain DETAB-E351

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KUY52_RS07325
• Protein ID: WP_000838146.1
• Coordinates: 1552289..1552471 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KUY52_RS07330
• Protein ID: WP_000966688.1
• Coordinates: 1552564..1552968 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUY52_RS07280 (KUY52_07295)	1547462..1547632	+	171	WP_005119785.1	hypothetical protein	-
KUY52_RS07285 (KUY52_07300)	1547644..1548048	+	405	WP_020752395.1	hypothetical protein	-
KUY52_RS07290 (KUY52_07305)	1548020..1548388	+	369	WP_002154735.1	hypothetical protein	-
KUY52_RS07295 (KUY52_07310)	1548390..1548788	+	399	WP_038338646.1	phage tail terminator-like protein	-
KUY52_RS07300 (KUY52_07315)	1548790..1549008	+	219	WP_032023387.1	hypothetical protein	-
KUY52_RS07305 (KUY52_07320)	1549067..1549420	+	354	WP_038338649.1	hypothetical protein	-
KUY52_RS07310 (KUY52_07325)	1549420..1550406	+	987	WP_038338650.1	hypothetical protein	-
KUY52_RS07315 (KUY52_07330)	1550459..1551376	+	918	WP_038338651.1	phage tail tube protein	-
KUY52_RS07320 (KUY52_07335)	1551448..1551963	+	516	WP_038338655.1	hypothetical protein	-
KUY52_RS07325 (KUY52_07340)	1552289..1552471	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KUY52_RS07330 (KUY52_07345)	1552564..1552968	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KUY52_RS07335 (KUY52_07350)	1553067..1553585	+	519	WP_004793706.1	DUF4468 domain-containing protein	-
KUY52_RS07340 (KUY52_07355)	1553650..1554150	+	501	WP_004793705.1	hypothetical protein	-
KUY52_RS07345 (KUY52_07360)	1554273..1554431	+	159	WP_004793704.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1518974..1572404	53430

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T208046 WP_000838146.1 NZ_CP077828:1552289-1552471 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T208046 NZ_CP103560:324280-324648 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT208046 WP_000966688.1 NZ_CP077828:1552564-1552968 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT208046 NZ_CP103560:324062-324283 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6