Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2555642..2557230 Replicon chromosome
Accession NZ_CP077824
Organism Klebsiella pneumoniae strain FF1009

Toxin (Protein)


Gene name hipA Uniprot ID A0A6G4M3Z0
Locus tag KU661_RS12270 Protein ID WP_065800700.1
Coordinates 2555908..2557230 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KU661_RS12265 Protein ID WP_002904790.1
Coordinates 2555642..2555908 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU661_RS12240 (KU661_12205) 2550793..2551716 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
KU661_RS12245 (KU661_12210) 2551697..2552851 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KU661_RS12250 (KU661_12215) 2553197..2554576 + 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
KU661_RS12255 (KU661_12220) 2554554..2555054 + 501 WP_065800699.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KU661_RS12260 (KU661_12225) 2555051..2555377 + 327 WP_021462560.1 hydroxyisourate hydrolase -
KU661_RS12265 (KU661_12230) 2555642..2555908 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KU661_RS12270 (KU661_12235) 2555908..2557230 + 1323 WP_065800700.1 type II toxin-antitoxin system HipA family toxin Toxin
KU661_RS12275 (KU661_12240) 2557247..2558539 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KU661_RS12280 (KU661_12245) 2558672..2559676 - 1005 WP_065800701.1 fimbrial protein -
KU661_RS12285 (KU661_12250) 2559664..2562165 - 2502 WP_065800702.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49153.49 Da        Isoelectric Point: 7.5357

>T208032 WP_065800700.1 NZ_CP077824:2555908-2557230 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVIRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T208032 NZ_CP103559:2543917-2544093 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT208032 WP_002904790.1 NZ_CP077824:2555642-2555908 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT208032 NZ_CP103559:2544139-2544555 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G4M3Z0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References