Detailed information of TA system TA020793

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2063981..2064206
• Replicon: chromosome
• Accession: NC_004337
• Organism: Shigella flexneri 2a str. 301

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: SF2042b
• Protein ID: YP_008439262.1
• Coordinates: 2063981..2064193 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2064148..2064206 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SF2036	2059296..2059643	-	348	NP_707872.1	insertion sequence element ISSfl4 ORF2	-
SF2037	2059640..2060314	-	675	NP_707873.1	insertion sequence element ISSfl4 transposase	-
SF2038	2060413..2060628	-	216	NP_707874.1	lysis protein S	-
SF2039	2061429..2062112	-	684	NP_707875.2	Q antiterminator of prophage	-
SF2040	2062109..2062474	-	366	NP_707876.1	crossover junction endodeoxyribonuclease	-
SF2041	2062475..2063461	-	987	NP_707877.2	bacteriophage protein	-
SF2042	2063535..2063813	-	279	NP_707878.1	hypothetical protein	-
SF2042a	2063616..2063939	+	324	YP_008439261.1	hypothetical protein	-
SF2042b	2063981..2064193	-	213	YP_008439262.1	regulatory protein	Toxin
-	2064148..2064206	+	59	-	-	Antitoxin
SF2042c	2064396..2064614	-	219	YP_008439263.1	membrane protein	-
SF2043	2064788..2065123	-	336	NP_707879.2	bacteriophage protein	-
SF2045	2066593..2067429	+	837	NP_707881.1	DgsA anti-repressor MtfA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	2045222..2091085	45863

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7856.42 Da
• Isoelectric Point: 8.7469

>T20793 YP_008439262.1 NC_004337:c2064193-2063981 [Shigella flexneri 2a str. 301]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T20793 NC_004337:c2064193-2063981 [Shigella flexneri 2a str. 301]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT20793 NC_004337:2064148-2064206 [Shigella flexneri 2a str. 301]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin