Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2295068..2296065 Replicon chromosome
Accession NZ_CP077805
Organism Klebsiella variicola strain FF907

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KU664_RS11185 Protein ID WP_233445594.1
Coordinates 2295511..2296065 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KU664_RS11180 Protein ID WP_047666809.1
Coordinates 2295068..2295514 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU664_RS11165 (KU664_11135) 2291363..2292361 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
KU664_RS11170 (KU664_11140) 2292480..2294000 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
KU664_RS11175 (KU664_11145) 2294016..2295026 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
KU664_RS11180 (KU664_11150) 2295068..2295514 - 447 WP_047666809.1 helix-turn-helix transcriptional regulator Antitoxin
KU664_RS11185 2295511..2296065 - 555 WP_233445594.1 HipA domain-containing protein Toxin
KU664_RS11190 2296094..2296615 - 522 WP_023340544.1 hypothetical protein -
KU664_RS11195 (KU664_11160) 2296730..2297461 - 732 WP_008804033.1 outer membrane permeability protein SanA -
KU664_RS11200 (KU664_11165) 2297673..2298557 - 885 WP_012541034.1 cytidine deaminase -
KU664_RS11205 (KU664_11170) 2298686..2299381 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
KU664_RS11210 (KU664_11175) 2299371..2299775 - 405 WP_023340543.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20741.01 Da        Isoelectric Point: 5.7976

>T207840 WP_233445594.1 NZ_CP077805:c2296065-2295511 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQDFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFASMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDTLLNALRETASQLVDLPARLKARGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

>T207840 NZ_CP103521:c3954204-3953806 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16424.11 Da        Isoelectric Point: 10.5417

>AT207840 WP_047666809.1 NZ_CP077805:c2295514-2295068 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRVDNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT207840 NZ_CP103521:c3954500-3954207 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References