Detailed information of TA system TA207838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1384516..1385291
• Replicon: chromosome
• Accession: NZ_CP077805
• Organism: Klebsiella variicola strain FF907

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: KU664_RS06660
• Protein ID: WP_060875993.1
• Coordinates: 1384806..1385291 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: W8UEW1
• Locus tag: KU664_RS06655
• Protein ID: WP_004150912.1
• Coordinates: 1384516..1384809 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU664_RS06635 (KU664_06620)	1379772..1380374	-	603	WP_012540553.1	short chain dehydrogenase	-
KU664_RS06640 (KU664_06625)	1380472..1381383	+	912	WP_012540554.1	LysR family transcriptional regulator	-
KU664_RS06645 (KU664_06630)	1381384..1382532	-	1149	WP_008806488.1	PLP-dependent aspartate aminotransferase family protein	-
KU664_RS06650 (KU664_06635)	1382544..1383920	-	1377	WP_251347008.1	cystathionine beta-synthase	-
KU664_RS06655 (KU664_06640)	1384516..1384809	+	294	WP_004150912.1	DUF1778 domain-containing protein	Antitoxin
KU664_RS06660 (KU664_06645)	1384806..1385291	+	486	WP_060875993.1	GNAT family N-acetyltransferase	Toxin
KU664_RS06665 (KU664_06650)	1385995..1386588	+	594	WP_004188553.1	hypothetical protein	-
KU664_RS06670 (KU664_06655)	1386685..1386901	+	217	Protein_1284	transposase	-
KU664_RS06680 (KU664_06665)	1387416..1388129	-	714	WP_008806478.1	DUF554 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1386685..1386837	152

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-95)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17644.67 Da
• Isoelectric Point: 8.5057

>T207838 WP_060875993.1 NZ_CP077805:1384806-1385291 [Klebsiella variicola]
MISAPEPLHAGHILTPFCCGIDSMDYWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVH
A

Nucleotide

• Length: 486 bp

>T207838 NZ_CP103521:3740136-3740354 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10901.46 Da
• Isoelectric Point: 6.3783

>AT207838 WP_004150912.1 NZ_CP077805:1384516-1384809 [Klebsiella variicola]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Nucleotide

• Length: 294 bp

>AT207838 NZ_CP103521:3739736-3740110 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GVL4