Detailed information of TA system TA207794

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 139732..139985
• Replicon: plasmid pCDI694-140.8
• Accession: NZ_CP077777
• Organism: Klebsiella pneumoniae strain CDI694

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: KUM43_RS28505
• Protein ID: WP_001312851.1
• Coordinates: 139836..139985 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	139732..139791 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUM43_RS28465 (135114)	135114..135458	-	345	Protein_178	IS6-like element IS26 family transposase	-
KUM43_RS28470 (135510)	135510..136214	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
KUM43_RS28475 (136239)	136239..136439	+	201	WP_072354025.1	hypothetical protein	-
KUM43_RS28480 (136459)	136459..137205	+	747	WP_000205770.1	conjugal transfer pilus acetylase TraX	-
KUM43_RS28485 (137260)	137260..137820	+	561	WP_000139328.1	fertility inhibition protein FinO	-
KUM43_RS28490 (137952)	137952..138152	+	201	WP_015059022.1	hypothetical protein	-
KUM43_RS28495 (138538)	138538..139137	+	600	WP_032083981.1	PIN domain-containing protein	-
KUM43_RS28500 (139199)	139199..139531	+	333	WP_152916585.1	hypothetical protein	-
- (139732)	139732..139791	-	60	NuclAT_1	-	Antitoxin
- (139732)	139732..139791	-	60	NuclAT_1	-	Antitoxin
- (139732)	139732..139791	-	60	NuclAT_1	-	Antitoxin
- (139732)	139732..139791	-	60	NuclAT_1	-	Antitoxin
KUM43_RS28505 (139836)	139836..139985	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
KUM43_RS28510 (140269)	140269..140517	+	249	WP_000083837.1	replication regulatory protein RepA	-
KUM43_RS29925 (140632)	140632..140816	+	185	Protein_188	protein CopA/IncA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-65 / blaSHV-12 / blaKPC-2	-	1..140828	140828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T207794 WP_001312851.1 NZ_CP077777:139836-139985 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T207794 NZ_CP103514:119275-119625 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT207794 NZ_CP077777:c139791-139732 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin