Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2263213..2263411 Replicon chromosome
Accession NZ_CP077738
Organism Staphylococcus aureus strain UMCG578

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag KTE14_RS11190 Protein ID WP_001802298.1
Coordinates 2263307..2263411 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2263213..2263251 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTE14_RS11165 (KTE14_11085) 2259333..2259998 - 666 WP_001024099.1 SDR family oxidoreductase -
KTE14_RS11170 (KTE14_11090) 2260150..2260470 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
KTE14_RS11175 (KTE14_11095) 2260472..2261452 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
KTE14_RS11180 (KTE14_11100) 2261718..2262809 + 1092 WP_000495673.1 hypothetical protein -
KTE14_RS11185 2263193..2263267 + 75 Protein_2162 hypothetical protein -
- 2263213..2263251 + 39 - - Antitoxin
KTE14_RS11190 (KTE14_11105) 2263307..2263411 - 105 WP_001802298.1 hypothetical protein Toxin
KTE14_RS11195 (KTE14_11110) 2264091..2264249 + 159 WP_001792784.1 hypothetical protein -
KTE14_RS11200 (KTE14_11115) 2264685..2264777 + 93 WP_000220902.1 hypothetical protein -
KTE14_RS11205 (KTE14_11120) 2264907..2265764 - 858 WP_000370942.1 HAD family hydrolase -
KTE14_RS11210 (KTE14_11125) 2265832..2266614 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
KTE14_RS11215 (KTE14_11130) 2266904..2267512 - 609 WP_000101714.1 TIR domain-containing protein -
KTE14_RS11220 (KTE14_11135) 2267540..2268079 - 540 WP_223596973.1 toll/interleukin-1 receptor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2268240..2269412 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T207679 WP_001802298.1 NZ_CP077738:c2263411-2263307 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T207679 NZ_CP103468:c4594920-4594747 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 39 bp

>AT207679 NZ_CP077738:2263213-2263251 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References