Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 891842..892502 Replicon chromosome
Accession NZ_CP077706
Organism Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag DAX52_RS04295 Protein ID WP_000244757.1
Coordinates 892089..892502 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAX52_RS04290 Protein ID WP_000351186.1
Coordinates 891842..892108 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX52_RS04270 (887770) 887770..889203 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
DAX52_RS04275 (889362) 889362..889673 + 312 WP_058344418.1 N(4)-acetylcytidine aminohydrolase -
DAX52_RS04280 (889837) 889837..890496 + 660 WP_000250289.1 hemolysin III family protein -
DAX52_RS04285 (890612) 890612..891592 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
DAX52_RS04290 (891842) 891842..892108 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAX52_RS04295 (892089) 892089..892502 + 414 WP_000244757.1 protein YgfX Toxin
DAX52_RS04300 (892555) 892555..893076 - 522 WP_001055885.1 flavodoxin FldB -
DAX52_RS04305 (893189) 893189..894085 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DAX52_RS04310 (894109) 894109..894822 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAX52_RS04315 (894828) 894828..896561 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T207604 WP_000244757.1 NZ_CP077706:892089-892502 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T207604 NZ_CP103421:20517-20849 [Klebsiella variicola]
ATGGTAAAACGCTACGTACCGGATGCTGGTGACCTTATTTGGATAGATTTCGATCCGGTTGCCGGGCATGAGCAGGGAGG
ACACCGGCCTGCTGTTGTCCTTAGTCCTTTCGCCTACAACAACAAGGTTGGTCTGCTGTTGTGTGTGCCATGCACTACGC
AAATCAAGGGCTACCCCTTTGAAGTCACGCTATCTGGTAGCAAAGAAGGCGTGGCGCTGTCGGATCAGGTTACATGCGTT
GACTGGCGGGCCAGGAAAGTGAGCAAGAAGGACGCGGTTAACAGTACAGAACTGGCAGAAATAAGGGCAAAAGCGAAAGC
GCTGATTGGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207604 WP_000351186.1 NZ_CP077706:891842-892108 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207604 NZ_CP103421:20272-20517 [Klebsiella variicola]
ATGGCTCAGGCAATAGTAAAAAAATGGGGTAACAGCCCGTCTGTCCGGTTGCCAGTAGCGGTGATGAAAGCTGCGTCACT
AAACGTTGATGATACTGTCGATATAGAGGTTGAGGATGGTCGTATCATCATTGTTCCTGTCAGACAGAAAGAGTATTCCC
TCGATGCATTGCTGGCCGGGATTTCCACCGATAATTTGCATGGCAAAGCAGATTTCGGCCCGGCAGAGGGTAAGGAACTG
CTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References