Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2387744..2388266 Replicon chromosome
Accession NZ_CP077696
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag DAX72_RS11395 Protein ID WP_000221344.1
Coordinates 2387982..2388266 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DAX72_RS11390 Protein ID WP_000885424.1
Coordinates 2387744..2387992 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS11360 (2382912) 2382912..2383127 + 216 WP_001530185.1 hypothetical protein -
DAX72_RS24485 (2383562) 2383562..2383978 + 417 WP_258230083.1 hypothetical protein -
DAX72_RS24490 (2383994) 2383994..2384485 + 492 WP_258230084.1 hypothetical protein -
DAX72_RS11370 (2384900) 2384900..2385475 + 576 Protein_2253 helix-turn-helix domain-containing protein -
DAX72_RS11375 (2385546) 2385546..2386496 - 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
DAX72_RS11380 (2386660) 2386660..2386992 - 333 WP_000253166.1 DUF1493 family protein -
DAX72_RS11385 (2386986) 2386986..2387444 - 459 WP_000381836.1 hypothetical protein -
DAX72_RS11390 (2387744) 2387744..2387992 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DAX72_RS11395 (2387982) 2387982..2388266 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX72_RS11400 (2388385) 2388385..2388666 + 282 Protein_2259 RidA family protein -
DAX72_RS11405 (2388718) 2388718..2389797 - 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DAX72_RS11410 (2389990) 2389990..2390478 - 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
DAX72_RS11415 (2390523) 2390523..2392031 + 1509 WP_108411764.1 FAD-dependent oxidoreductase -
DAX72_RS11420 (2392021) 2392021..2393262 + 1242 WP_001095723.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2380612..2394888 14276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T207537 WP_000221344.1 NZ_CP077696:2387982-2388266 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T207537 NZ_CP103330:86839-88164 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT207537 WP_000885424.1 NZ_CP077696:2387744-2387992 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT207537 NZ_CP103330:86541-86834 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References