Detailed information of TA system TA207512

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2979004..2979229
• Replicon: chromosome
• Accession: NZ_CP077693
• Organism: Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: A0A636EVM3
• Locus tag: DAY14_RS14685
• Protein ID: WP_001597144.1
• Coordinates: 2979004..2979159 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2979171..2979229 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAY14_RS14660	2975770..2976810	+	1041	WP_065618880.1	DNA cytosine methyltransferase	-
DAY14_RS14665	2976819..2977172	-	354	WP_071645503.1	antiterminator Q family protein	-
DAY14_RS14670	2977165..2977524	-	360	Protein_2888	RusA family crossover junction endodeoxyribonuclease	-
DAY14_RS14675	2977521..2977802	-	282	WP_050942040.1	DUF1364 family protein	-
DAY14_RS25930	2977799..2977993	-	195	WP_024136025.1	hypothetical protein	-
DAY14_RS14680	2977990..2978427	-	438	WP_000023105.1	recombination protein NinB	-
DAY14_RS25935	2978457..2978537	-	81	Protein_2892	hypothetical protein	-
DAY14_RS14685	2979004..2979159	-	156	WP_001597144.1	Hok/Gef family protein	Toxin
-	2979171..2979229	+	59	-	-	Antitoxin
DAY14_RS14690	2979362..2979634	-	273	WP_024153615.1	hypothetical protein	-
DAY14_RS14695	2979631..2980026	-	396	WP_108441221.1	DUF977 family protein	-
DAY14_RS14700	2980026..2980649	-	624	WP_024153613.1	DUF1627 domain-containing protein	-
DAY14_RS14705	2980669..2981412	-	744	WP_024153612.1	ATP-binding protein	-
DAY14_RS14710	2981419..2982294	-	876	WP_070808393.1	DNA-binding protein	-
DAY14_RS14715	2982338..2982832	-	495	WP_024153611.1	toxin YdaT family protein	-
DAY14_RS14720	2982829..2983104	-	276	WP_024153610.1	YdaS family helix-turn-helix protein	-
DAY14_RS14725	2983176..2983670	+	495	WP_024153609.1	helix-turn-helix transcriptional regulator	-
DAY14_RS14730	2983864..2984019	+	156	WP_071606037.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	pipB	2945690..2994834	49144

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5742.91 Da
• Isoelectric Point: 6.1531

>T207512 WP_001597144.1 NZ_CP077693:c2979159-2979004 [Salmonella enterica subsp. enterica]
MKQQKAMLIALIVICITVVMAVLVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T207512 NZ_CP103315:c5413318-5412935 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT207512 NZ_CP077693:2979171-2979229 [Salmonella enterica subsp. enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A636EVM3

Antitoxin