Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4289203..4289895 Replicon chromosome
Accession NZ_CP077691
Organism Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)


Gene name ykfI Uniprot ID A0A737B651
Locus tag DAX98_RS21035 Protein ID WP_020437644.1
Coordinates 4289203..4289541 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A737AZQ1
Locus tag DAX98_RS21040 Protein ID WP_031250916.1
Coordinates 4289566..4289895 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX98_RS21015 (4284896) 4284896..4285612 + 717 WP_000532939.1 YebC/PmpR family DNA-binding transcriptional regulator -
DAX98_RS21020 (4286091) 4286091..4286966 - 876 WP_020437647.1 HNH endonuclease -
DAX98_RS21025 (4287315) 4287315..4288112 - 798 WP_020437646.1 helix-turn-helix transcriptional regulator -
DAX98_RS21030 (4288256) 4288256..4289089 - 834 WP_020437645.1 DUF4942 domain-containing protein -
DAX98_RS21035 (4289203) 4289203..4289541 - 339 WP_020437644.1 TA system toxin CbtA family protein Toxin
DAX98_RS21040 (4289566) 4289566..4289895 - 330 WP_031250916.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DAX98_RS21045 (4289919) 4289919..4290398 - 480 WP_023197794.1 DNA repair protein RadC -
DAX98_RS21050 (4290419) 4290419..4290685 - 267 WP_020437641.1 hypothetical protein -
DAX98_RS21055 (4291151) 4291151..4291774 + 624 WP_023222165.1 inovirus Gp2 family protein -
DAX98_RS21060 (4291893) 4291893..4292108 + 216 WP_020437639.1 AlpA family transcriptional regulator -
DAX98_RS21065 (4292653) 4292653..4294344 - 1692 WP_020437638.1 YfjI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4281348..4299827 18479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(6-107)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12783.72 Da        Isoelectric Point: 8.5135

>T207496 WP_020437644.1 NZ_CP077691:c4289541-4289203 [Salmonella enterica subsp. enterica]
MKILSANQRVAKPCPPPVLVWQTLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQNQLPSTR

Download         Length: 339 bp

>T207496 NZ_CP103307:c3921670-3920801 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12431.03 Da        Isoelectric Point: 6.3196

>AT207496 WP_031250916.1 NZ_CP077691:c4289895-4289566 [Salmonella enterica subsp. enterica]
MDKETDTVQWGLNRPGSPQFSARLVQEGKRLHYLADRAGITGAFNEEECHQLNAAFPHFVKQMELMLLSGELNPRHAYRV
TLYHNELTCEADTLGSCGYVYIAIYPTQR

Download         Length: 330 bp

>AT207496 NZ_CP103307:c3920808-3919975 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A737B651

Antitoxin

Source ID Structure
AlphaFold DB A0A737AZQ1

References