Detailed information of TA system TA207373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4639474..4640076
• Replicon: chromosome
• Accession: NZ_CP077662
• Organism: Salmonella enterica strain S146

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Y7R225
• Locus tag: KTP10_RS22350
• Protein ID: WP_023232499.1
• Coordinates: 4639765..4640076 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KTP10_RS22345
• Protein ID: WP_000362050.1
• Coordinates: 4639474..4639764 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP10_RS22330 (4636967)	4636967..4637869	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
KTP10_RS22335 (4637866)	4637866..4638501	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KTP10_RS22340 (4638498)	4638498..4639427	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
KTP10_RS22345 (4639474)	4639474..4639764	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KTP10_RS22350 (4639765)	4639765..4640076	-	312	WP_023232499.1	hypothetical protein	Toxin
KTP10_RS22355 (4640294)	4640294..4641223	+	930	WP_023232500.1	alpha/beta hydrolase	-
KTP10_RS22360 (4641309)	4641309..4641620	+	312	WP_000558164.1	type II toxin-antitoxin system HigB family toxin	-
KTP10_RS22365 (4641617)	4641617..4642063	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
KTP10_RS22370 (4642078)	4642078..4643019	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KTP10_RS22375 (4643064)	4643064..4643501	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
KTP10_RS22380 (4643498)	4643498..4644367	-	870	WP_023203606.1	virulence factor BrkB family protein	-
KTP10_RS22385 (4644361)	4644361..4644960	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12388.34 Da
• Isoelectric Point: 9.4460

>T207373 WP_023232499.1 NZ_CP077662:c4640076-4639765 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGVRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207373 NZ_CP102970:c2451960-2451694 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207373 WP_000362050.1 NZ_CP077662:c4639764-4639474 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207373 NZ_CP102970:c2452211-2451960 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A3Y7R225