Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 916222..916882 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KTP10_RS04455 Protein ID WP_000244756.1
Coordinates 916469..916882 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KTP10_RS04450 Protein ID WP_000351186.1
Coordinates 916222..916488 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS04430 (912151) 912151..913584 - 1434 WP_023232670.1 6-phospho-beta-glucosidase BglA -
KTP10_RS04435 (913742) 913742..914053 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KTP10_RS04440 (914217) 914217..914876 + 660 WP_000250289.1 hemolysin III family protein -
KTP10_RS04445 (914992) 914992..915972 - 981 WP_023232672.1 tRNA-modifying protein YgfZ -
KTP10_RS04450 (916222) 916222..916488 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KTP10_RS04455 (916469) 916469..916882 + 414 WP_000244756.1 protein YgfX Toxin
KTP10_RS04460 (916935) 916935..917456 - 522 WP_001055885.1 flavodoxin FldB -
KTP10_RS04465 (917569) 917569..918465 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KTP10_RS04470 (918489) 918489..919202 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTP10_RS04475 (919208) 919208..920941 + 1734 WP_023181521.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T207355 WP_000244756.1 NZ_CP077662:916469-916882 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207355 NZ_CP102966:c2417290-2417024 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207355 WP_000351186.1 NZ_CP077662:916222-916488 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207355 NZ_CP102966:c2417541-2417290 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References