Detailed information of TA system TA207320

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4127711..4128429
• Replicon: chromosome
• Accession: NZ_CP077659
• Organism: Enterobacter cloacae complex sp. ECL72

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A822WUK4
• Locus tag: KTH07_RS19930
• Protein ID: WP_071605960.1
• Coordinates: 4128109..4128429 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A822X2D3
• Locus tag: KTH07_RS19925
• Protein ID: WP_054627869.1
• Coordinates: 4127711..4128067 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTH07_RS19895	4124062..4124496	+	435	WP_054627865.1	hypothetical protein	-
KTH07_RS19900	4124556..4125122	+	567	WP_063162103.1	hypothetical protein	-
KTH07_RS19905	4125156..4125395	+	240	WP_063162102.1	hypothetical protein	-
KTH07_RS19910	4126088..4126909	+	822	WP_044599778.1	DUF932 domain-containing protein	-
KTH07_RS19915	4126979..4127449	+	471	WP_032294514.1	DNA repair protein RadC	-
KTH07_RS19920	4127458..4127679	+	222	WP_054627868.1	DUF987 family protein	-
KTH07_RS19925	4127711..4128067	+	357	WP_054627869.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KTH07_RS19930	4128109..4128429	+	321	WP_071605960.1	TA system toxin CbtA family protein	Toxin
KTH07_RS19935	4128633..4129214	+	582	WP_017383635.1	hypothetical protein	-
KTH07_RS19940	4129216..4129407	-	192	WP_032620729.1	toxin-antitoxin system HicB family antitoxin	-
KTH07_RS19945	4129544..4129885	+	342	WP_032620730.1	SymE family type I addiction module toxin	-
KTH07_RS19950	4129944..4130972	+	1029	WP_071842900.1	RhuM family protein	-
KTH07_RS19955	4131236..4131721	+	486	WP_017383637.1	type VI secretion system tube protein TssD	-
KTH07_RS19960	4131731..4132096	+	366	WP_023302859.1	DUF2778 domain-containing protein	-
KTH07_RS19965	4132093..4132680	+	588	WP_023295690.1	hypothetical protein	-
KTH07_RS19970	4132713..4133156	-	444	WP_017383639.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4107445..4137035	29590

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12227.83 Da
• Isoelectric Point: 6.3229

>T207320 WP_071605960.1 NZ_CP077659:4128109-4128429 [Enterobacter cloacae complex sp. ECL72]
MHISTVPKTVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKSF
SWQDQEPWITSLDVHRAQSNLGLKRP

Nucleotide

• Length: 321 bp

>T207320 NZ_CP102958:c2361031-2360765 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13069.72 Da
• Isoelectric Point: 5.9473

>AT207320 WP_054627869.1 NZ_CP077659:4127711-4128067 [Enterobacter cloacae complex sp. ECL72]
MQSTTISGTSAENTSCLQWGLKRNITPCFGARLVQEGNRIYFLADRAGFNGSFSDAEALSLDQAFPLMVKQLERMLTTGE
LDPHNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL

Nucleotide

• Length: 357 bp

>AT207320 NZ_CP102958:c2361282-2361031 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A822WUK4

Antitoxin

• AlphaFold DB: A0A822X2D3