Detailed information of TA system TA207245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4147..4790
• Replicon: chromosome
• Accession: NZ_CP077638
• Organism: Methylorubrum extorquens strain PA1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KQ926_RS00020
• Protein ID: WP_012251833.1
• Coordinates: 4147..4551 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KQ926_RS00025
• Protein ID: WP_012251834.1
• Coordinates: 4551..4790 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ926_RS00005 (KQ926_00005)	1..1506	+	1506	WP_012251830.1	chromosomal replication initiator protein DnaA	-
KQ926_RS00010 (KQ926_00010)	1827..2948	+	1122	WP_012251831.1	DNA polymerase III subunit beta	-
KQ926_RS00015 (KQ926_00015)	2989..4143	+	1155	WP_012251832.1	DNA replication/repair protein RecF	-
KQ926_RS00020 (KQ926_00020)	4147..4551	-	405	WP_012251833.1	type II toxin-antitoxin system VapC family toxin	Toxin
KQ926_RS00025 (KQ926_00025)	4551..4790	-	240	WP_012251834.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KQ926_RS00030 (KQ926_00030)	4893..6740	+	1848	WP_012251835.1	DNA helicase RecQ	-
KQ926_RS00035 (KQ926_00035)	6798..7136	-	339	WP_012251836.1	hypothetical protein	-
KQ926_RS00040 (KQ926_00040)	7452..8138	+	687	WP_003598308.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-128)

Antitoxin

• Antitoxin VapB-like (1-75)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14308.34 Da
• Isoelectric Point: 5.1418

>T207245 WP_012251833.1 NZ_CP077638:c4551-4147 [Methylorubrum extorquens]
MFVDASAIIAIIAREPQAETLTARLEEAPVRYTSAVAVLETVMALRRLGAGSIAQAEQLVRHLLEHADIEEVPITTRESA
AAIAAYARYGKGQGHPAQLNLGDCFAYACARTRNVPLLFVGNDFSQTDIAAALA

Nucleotide

• Length: 405 bp

>T207245 NZ_CP102947:187388-187495 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8977.27 Da
• Isoelectric Point: 10.0862

>AT207245 WP_012251834.1 NZ_CP077638:c4790-4551 [Methylorubrum extorquens]
MPLNIRSEEVNRLAEKLASQARVSKTEAVRMALANELQRRESSLPLSERIKPIQDAFARWPKTGMKADKAFFDDMNGES

Nucleotide

• Length: 240 bp

>AT207245 NZ_CP102947:c187339-187274 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT