Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3153..3675 Replicon plasmid unnamed
Accession NZ_CP077406
Organism Citrobacter braakii strain FDAARGOS 1421

Toxin (Protein)


Gene name parE Uniprot ID A0A1V8NRN7
Locus tag I6L51_RS26970 Protein ID WP_040233134.1
Coordinates 3153..3440 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1V8NRN8
Locus tag I6L51_RS26975 Protein ID WP_040233135.1
Coordinates 3433..3675 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L51_RS26960 (I6L51_26960) 1361..2428 + 1068 WP_040233132.1 pesticin C-terminus-like muramidase -
I6L51_RS26965 (I6L51_26965) 2464..2955 - 492 WP_139816532.1 lysozyme inhibitor LprI family protein -
I6L51_RS26970 (I6L51_26970) 3153..3440 - 288 WP_040233134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L51_RS26975 (I6L51_26975) 3433..3675 - 243 WP_040233135.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
I6L51_RS26980 (I6L51_26980) 4104..4523 + 420 WP_040233136.1 hypothetical protein -
I6L51_RS26985 (I6L51_26985) 4622..5326 - 705 WP_143329759.1 hypothetical protein -
I6L51_RS26990 (I6L51_26990) 5586..6590 + 1005 WP_052463781.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18541 18541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11089.69 Da        Isoelectric Point: 5.0101

>T207147 WP_040233134.1 NZ_CP077406:c3440-3153 [Citrobacter braakii]
MVKTYRLSPLAEADLEEIWLYTLRNWSIVQADNYHHDLVATFEALANGMKFGLPSVLPEYQKCLCGSHVVYFLDYTDCVD
IIRILHQRQDADLHF

Download         Length: 288 bp

>T207147 NZ_CP102898:3998763-3998981 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8821.83 Da        Isoelectric Point: 7.4045

>AT207147 WP_040233135.1 NZ_CP077406:c3675-3433 [Citrobacter braakii]
MRQNTSVALGPHFSSFVDAQVQGGRYGSASDVIRAGLRLLEEHEARVKALQEALIAGRESGEPRSFDSEAFLRRMHTQHG

Download         Length: 243 bp

>AT207147 NZ_CP102898:3998362-3998736 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V8NRN7

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8NRN8

References