Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2304926..2306499 Replicon chromosome
Accession NZ_CP077237
Organism Aeromonas sp. FDAARGOS 1404

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I6L34_RS10730 Protein ID WP_216956807.1
Coordinates 2305180..2306499 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6L34_RS10725 Protein ID WP_017410478.1
Coordinates 2304926..2305180 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L34_RS10710 (I6L34_10710) 2300908..2302812 - 1905 WP_216956803.1 AAA family ATPase -
I6L34_RS10715 (I6L34_10715) 2303450..2303773 + 324 WP_101778626.1 hypothetical protein -
I6L34_RS10720 (I6L34_10720) 2303770..2304387 - 618 WP_216956805.1 recombinase family protein -
I6L34_RS10725 (I6L34_10725) 2304926..2305180 + 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
I6L34_RS10730 (I6L34_10730) 2305180..2306499 + 1320 WP_216956807.1 type II toxin-antitoxin system HipA family toxin Toxin
I6L34_RS10735 (I6L34_10735) 2306920..2308902 - 1983 WP_216956809.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
I6L34_RS10740 (I6L34_10740) 2308899..2309783 - 885 WP_204382776.1 ABC transporter substrate-binding protein -
I6L34_RS10745 (I6L34_10745) 2309818..2310582 - 765 WP_204382375.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2281618..2306499 24881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49559.53 Da        Isoelectric Point: 6.5054

>T206837 WP_216956807.1 NZ_CP077237:2305180-2306499 [Aeromonas sp. FDAARGOS 1404]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELKQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGLWYLPLNVTPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMETLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T206837 NZ_CP102694:c4210666-4210493 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT206837 WP_017410478.1 NZ_CP077237:2304926-2305180 [Aeromonas sp. FDAARGOS 1404]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT206837 NZ_CP102694:c4210990-4210694 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References