Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 38023..38762 Replicon plasmid unnamed1
Accession NZ_CP077212
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag I6L61_RS26035 Protein ID WP_013087269.1
Coordinates 38023..38508 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag I6L61_RS26040 Protein ID WP_007869691.1
Coordinates 38496..38762 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS26010 (33362) 33362..34509 + 1148 WP_139153290.1 IS3 family transposase -
I6L61_RS26015 (34617) 34617..35126 + 510 WP_013087265.1 DUF2913 family protein -
I6L61_RS26020 (35260) 35260..36090 + 831 WP_100135202.1 hypothetical protein -
I6L61_RS26030 (36838) 36838..37656 + 819 WP_013087268.1 abortive infection family protein -
I6L61_RS26035 (38023) 38023..38508 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
I6L61_RS26040 (38496) 38496..38762 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
I6L61_RS26045 (39415) 39415..40428 + 1014 WP_013087098.1 plasmid replication initiator RepA -
I6L61_RS26050 (41379) 41379..42185 + 807 WP_013087100.1 DUF4225 domain-containing protein -
I6L61_RS26055 (42160) 42160..42489 - 330 WP_013087101.1 hypothetical protein -
I6L61_RS26060 (42572) 42572..42910 - 339 WP_013087102.1 hypothetical protein -
I6L61_RS26065 (42925) 42925..43695 - 771 WP_013087103.1 TraX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199566 199566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T206811 WP_013087269.1 NZ_CP077212:c38508-38023 [Enterobacter cloacae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T206811 NZ_CP102692:349429-349776 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT206811 WP_007869691.1 NZ_CP077212:c38762-38496 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT206811 NZ_CP102692:349776-350075 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References