Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1181394..1181996 Replicon chromosome
Accession NZ_CP077211
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1AN02
Locus tag I6L61_RS05560 Protein ID WP_013099360.1
Coordinates 1181394..1181705 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L61_RS05565 Protein ID WP_013099359.1
Coordinates 1181706..1181996 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS05530 (I6L61_05530) 1176420..1177220 + 801 WP_013099366.1 DeoR/GlpR family DNA-binding transcription regulator -
I6L61_RS05535 (I6L61_05535) 1177340..1177939 + 600 WP_013099365.1 glucose-1-phosphatase -
I6L61_RS05540 (I6L61_05540) 1177933..1178814 + 882 WP_013099364.1 virulence factor BrkB family protein -
I6L61_RS05545 (I6L61_05545) 1178811..1179248 + 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
I6L61_RS05550 (I6L61_05550) 1179293..1180234 + 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
I6L61_RS05555 (I6L61_05555) 1180247..1181164 - 918 WP_013099361.1 alpha/beta hydrolase -
I6L61_RS05560 (I6L61_05560) 1181394..1181705 + 312 WP_013099360.1 hypothetical protein Toxin
I6L61_RS05565 (I6L61_05565) 1181706..1181996 + 291 WP_013099359.1 helix-turn-helix domain-containing protein Antitoxin
I6L61_RS05570 (I6L61_05570) 1182039..1182968 - 930 WP_013099358.1 formate dehydrogenase accessory protein FdhE -
I6L61_RS05575 (I6L61_05575) 1182965..1183600 - 636 WP_013099357.1 formate dehydrogenase cytochrome b556 subunit -
I6L61_RS05580 (I6L61_05580) 1183597..1184499 - 903 WP_013099356.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12210.18 Da        Isoelectric Point: 9.7550

>T206797 WP_013099360.1 NZ_CP077211:1181394-1181705 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLATQPDYGDLIQNTGGLRKIRWLSGGRGKRGGVRVIYFHRTHEFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

>T206797 NZ_CP102687:184311-184413 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10623.13 Da        Isoelectric Point: 10.4747

>AT206797 WP_013099359.1 NZ_CP077211:1181706-1181996 [Enterobacter cloacae]
MDKALFERLTQSIAQMDDIVGGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVISALSD

Download         Length: 291 bp

>AT206797 NZ_CP102687:c184419-184275 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AN02

Antitoxin

Source ID Structure

References