Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 817145..817741 Replicon chromosome
Accession NZ_CP077211
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name PumA Uniprot ID A0A0M7H115
Locus tag I6L61_RS03845 Protein ID WP_029882644.1
Coordinates 817145..817447 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0F1AUP1
Locus tag I6L61_RS03850 Protein ID WP_013095028.1
Coordinates 817454..817741 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS03830 (I6L61_03830) 813624..814973 + 1350 WP_013095032.1 lysine-sensitive aspartokinase 3 -
I6L61_RS03835 (I6L61_03835) 815066..816010 + 945 WP_013095031.1 ketopantoate/pantoate/pantothenate transporter PanS -
I6L61_RS03840 (I6L61_03840) 816078..816947 - 870 WP_013095030.1 23S rRNA pseudouridine(2604) synthase RluF -
I6L61_RS03845 (I6L61_03845) 817145..817447 + 303 WP_029882644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L61_RS03850 (I6L61_03850) 817454..817741 + 288 WP_013095028.1 putative addiction module antidote protein Antitoxin
I6L61_RS03855 (I6L61_03855) 817738..819369 - 1632 WP_013095027.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11457.30 Da        Isoelectric Point: 9.7662

>T206795 WP_029882644.1 NZ_CP077211:817145-817447 [Enterobacter cloacae]
MKEIVQTESFRRWEQNLKDRRARTIIASRLFRLANGLAGDIKPVGEGICELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T206795 NZ_CP102682:480877-481200 [Leptospira borgpetersenii serovar Javanica]
ATGGTGATTTCTCAATACGAAGTATATTTGATAAATTTGGATCCAACGGTCGGACATGAGATTAAAAAATCAAGACCTTG
CGTAATAATCTCACCTAATGAAATGAATAAAACTATCGGAACAATTATTATTACACCAATGACTACAAAATCTCGATCAT
ATCCAACAAGAGTCGAATTAACATTTCAAGGAAAGAAAGGCTGGATTGTGTTAGATCAAATTCGAACTGTAGATAAAATA
CGTCTGATAAAAAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGATTATAAAGGAAATGTTGGTTGA
TTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10070.62 Da        Isoelectric Point: 5.7807

>AT206795 WP_013095028.1 NZ_CP077211:817454-817741 [Enterobacter cloacae]
MHKLTPYDPAIALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPAGD

Download         Length: 288 bp

>AT206795 NZ_CP102682:480635-480883 [Leptospira borgpetersenii serovar Javanica]
ATGAAGGCTTTAGTTGTAAAAATAGGTAATTCAAAAGGAATTCGGATTCCCAAAGCGGTTTTAGAAGAATGCCATATTGA
AGAAGAAGTAGATTTACTAATCGATAACAATAAATTAATTATTGTGCCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAATCAATGTCATCTAATAAAGATGATAAATTGCTTATTCCTGATTCAATAGATTTATCGGATAAGGATTGG
GAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M7H115

Antitoxin

Source ID Structure
AlphaFold DB A0A0F1AUP1

References