Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 452245..452761 Replicon chromosome
Accession NZ_CP077211
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name relE Uniprot ID A0A0M7F3X9
Locus tag I6L61_RS02040 Protein ID WP_013095355.1
Coordinates 452245..452529 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag I6L61_RS02045 Protein ID WP_008501400.1
Coordinates 452519..452761 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS02025 (I6L61_02025) 447499..449142 + 1644 WP_013095358.1 alpha,alpha-phosphotrehalase -
I6L61_RS02030 (I6L61_02030) 449516..451654 + 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
I6L61_RS02035 (I6L61_02035) 451777..452241 + 465 WP_013095356.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6L61_RS02040 (I6L61_02040) 452245..452529 - 285 WP_013095355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L61_RS02045 (I6L61_02045) 452519..452761 - 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6L61_RS02050 (I6L61_02050) 452839..454748 - 1910 Protein_398 BglG family transcription antiterminator -
I6L61_RS02055 (I6L61_02055) 454768..455907 - 1140 WP_100168201.1 lactonase family protein -
I6L61_RS02060 (I6L61_02060) 456031..456771 - 741 WP_013095353.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10986.92 Da        Isoelectric Point: 10.4251

>T206793 WP_013095355.1 NZ_CP077211:c452529-452245 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFKKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

>T206793 NZ_CP102680:2482093-2482494 [Leptospira borgpetersenii serovar Javanica]
ATGACTCAATACTTATTAGATACGAATATTTGCATTTATATAATAAACCAAAAGCCGAGATCTGTTTATAAAAAATTTAA
AAAGATCAAGTTAGAAAACATATTTATTTCATCAATTACGGAATTTGAATTAAAGTATGGTGTTCAAAAAAGTCTTCATT
TCGAAAGGAACTTAAAAATTTTAGAAGAGTTTTTAAGTTATTTGAATATTCTTTCATTTGTTAGTGAAGACGCAAATAAA
GCTGCAAAAATTCGAGTAGAATTAGACAAAGTAGGGAAACCAATCGGTCCTTTCGATCTTTTAATAGCTTCTCAAGCGTT
ATCGAATAAACTTACTCTCGTAACAAACAATGAAAAAGAGTTTACTCGGATCAAAGATATTAAAATTGCAAACTGGCTTT
AA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT206793 WP_008501400.1 NZ_CP077211:c452761-452519 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT206793 NZ_CP102680:2481866-2482096 [Leptospira borgpetersenii serovar Javanica]
ATGAATAAAGCTAAAATTTTTAAAAATGGGGATAGTCAAGCAATTCGTTTACCGAAAGACTATCGTTTCAAAGGCAAAGA
AGTCTATATACGAAGGGATGGAGATAATGTTATCTTAACACCAATAAACGATGCGGTTGATCGTTTTTGGAATACGGTTA
ATAGCTTTTCTGACGATCTTATACTTGATCGAAACCAACCAAACGAGTATGGCAAACGAAATAAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M7F3X9

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References