Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3467929..3468445 Replicon chromosome
Accession NZ_CP076863
Organism Klebsiella pneumoniae strain V3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KRP25_RS16860 Protein ID WP_217045542.1
Coordinates 3467929..3468213 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KRP25_RS16865 Protein ID WP_032456903.1
Coordinates 3468203..3468445 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP25_RS16835 (3463346) 3463346..3463654 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
KRP25_RS16840 (3463739) 3463739..3463912 + 174 WP_032431440.1 hypothetical protein -
KRP25_RS16845 (3463915) 3463915..3464658 + 744 WP_217045538.1 MurR/RpiR family transcriptional regulator -
KRP25_RS16850 (3465015) 3465015..3467153 + 2139 WP_217045540.1 anaerobic ribonucleoside-triphosphate reductase -
KRP25_RS16855 (3467461) 3467461..3467925 + 465 WP_156658125.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KRP25_RS16860 (3467929) 3467929..3468213 - 285 WP_217045542.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KRP25_RS16865 (3468203) 3468203..3468445 - 243 WP_032456903.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KRP25_RS16870 (3468523) 3468523..3470433 - 1911 WP_217045544.1 PRD domain-containing protein -
KRP25_RS16875 (3470456) 3470456..3471610 - 1155 WP_217045545.1 lactonase family protein -
KRP25_RS16880 (3471677) 3471677..3472417 - 741 WP_217045546.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11172.02 Da        Isoelectric Point: 10.3787

>T206592 WP_217045542.1 NZ_CP076863:c3468213-3467929 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T206592 NZ_CP102492:72900-73184 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8984.49 Da        Isoelectric Point: 5.1088

>AT206592 WP_032456903.1 NZ_CP076863:c3468445-3468203 [Klebsiella pneumoniae]
IATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPLPGVKVSLDDL

Download         Length: 243 bp

>AT206592 NZ_CP102492:72662-72910 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References