Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1881876..1882060 Replicon chromosome
Accession NZ_CP076839
Organism Staphylococcus aureus strain 55-100-016

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KRH48_RS08800 Protein ID WP_000482647.1
Coordinates 1881876..1881983 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1882000..1882060 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRH48_RS08775 (KRH48_08775) 1877233..1877706 + 474 WP_000456489.1 GyrI-like domain-containing protein -
KRH48_RS08780 (KRH48_08780) 1877829..1879040 - 1212 WP_001191974.1 multidrug effflux MFS transporter -
KRH48_RS08785 (KRH48_08785) 1879228..1879887 - 660 WP_000831300.1 hypothetical protein -
KRH48_RS08790 (KRH48_08790) 1879947..1881089 - 1143 WP_001176859.1 glycerate kinase -
KRH48_RS08795 (KRH48_08795) 1881356..1881742 + 387 WP_000779355.1 flippase GtxA -
KRH48_RS08800 (KRH48_08800) 1881876..1881983 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1882000..1882060 - 61 - - Antitoxin
KRH48_RS08805 (KRH48_08805) 1882687..1884450 + 1764 WP_001064818.1 ABC transporter ATP-binding protein -
KRH48_RS08810 (KRH48_08810) 1884475..1886208 + 1734 WP_000486511.1 ABC transporter ATP-binding protein -
KRH48_RS08815 (KRH48_08815) 1886439..1886606 + 168 WP_001798790.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T206532 WP_000482647.1 NZ_CP076839:1881876-1881983 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T206532 NZ_CP102479:1854099-1854202 [Klebsiella aerogenes]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT206532 NZ_CP076839:c1882060-1882000 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References