Detailed information of TA system TA206455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 4337393..4337925
• Replicon: chromosome
• Accession: NZ_CP076723
• Organism: Geomonas oryzisoli strain RG10

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KP004_RS18845
• Protein ID: WP_216799939.1
• Coordinates: 4337393..4337722 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: KP004_RS18850
• Protein ID: WP_216799940.1
• Coordinates: 4337719..4337925 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP004_RS18825 (KP004_18825)	4333961..4334638	-	678	WP_216799935.1	restriction endonuclease	-
KP004_RS18830 (KP004_18830)	4335545..4336195	-	651	WP_216799936.1	fibronectin type III domain-containing protein	-
KP004_RS18835 (KP004_18835)	4336562..4336864	+	303	WP_216799937.1	helix-turn-helix domain-containing protein	-
KP004_RS18840 (KP004_18840)	4336988..4337272	+	285	WP_216799938.1	DUF2442 domain-containing protein	-
KP004_RS18845 (KP004_18845)	4337393..4337722	-	330	WP_216799939.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KP004_RS18850 (KP004_18850)	4337719..4337925	-	207	WP_216799940.1	antitoxin MazE family protein	Antitoxin
KP004_RS18855 (KP004_18855)	4337981..4338517	-	537	WP_216799941.1	hypothetical protein	-
KP004_RS18860 (KP004_18860)	4339127..4340107	-	981	WP_216799942.1	hypothetical protein	-
KP004_RS18865 (KP004_18865)	4340441..4341895	-	1455	WP_216799943.1	NADH-quinone oxidoreductase subunit N	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4318848..4340107	21259

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Antitoxin MazE-like (5-67)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12011.99 Da
• Isoelectric Point: 7.9905

>T206455 WP_216799939.1 NZ_CP076723:c4337722-4337393 [Geomonas oryzisoli]
MKRGDVVLVTTAGDYGKPRPALVVQTDYFSEHPSVTLCLLTSFMLDAPLYRYKLAPTAENGLSAPSFVQVDKLMTVPRQK
VGDVIGNLSDKQMSEITRLLALWIGIADR

Nucleotide

• Length: 330 bp

>T206455 NZ_CP102435:325510-326043 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7821.76 Da
• Isoelectric Point: 4.2412

>AT206455 WP_216799940.1 NZ_CP076723:c4337925-4337719 [Geomonas oryzisoli]
MQPTRDRVQNYRAKLREAGLKPVQIWVPDPATPGFEAECLRQSRLALQDPQNLQDLEDMAEVADWGEE

Nucleotide

• Length: 207 bp

>AT206455 NZ_CP102435:325233-325499 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA