Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2288407..2289238 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KQ261_RS11600 Protein ID WP_000854815.1
Coordinates 2288864..2289238 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KQ261_RS11595 Protein ID WP_001280918.1
Coordinates 2288407..2288775 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS11550 (2283496) 2283496..2284242 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KQ261_RS11555 (2284325) 2284325..2284675 + 351 Protein_2279 hypothetical protein -
KQ261_RS11560 (2284691) 2284691..2285101 + 411 WP_000846703.1 hypothetical protein -
KQ261_RS11565 (2285322) 2285322..2286140 + 819 WP_001542275.1 DUF932 domain-containing protein -
KQ261_RS11570 (2286140) 2286140..2286385 + 246 WP_001164966.1 hypothetical protein -
KQ261_RS11575 (2286479) 2286479..2286952 + 474 WP_001542276.1 antirestriction protein -
KQ261_RS11580 (2286968) 2286968..2287444 + 477 WP_001186200.1 RadC family protein -
KQ261_RS11585 (2287507) 2287507..2287728 + 222 WP_000692345.1 DUF987 domain-containing protein -
KQ261_RS11590 (2287747) 2287747..2288391 + 645 WP_000086752.1 hypothetical protein -
KQ261_RS11595 (2288407) 2288407..2288775 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQ261_RS11600 (2288864) 2288864..2289238 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KQ261_RS11605 (2289235) 2289235..2289429 + 195 WP_000988600.1 DUF5983 family protein -
KQ261_RS11610 (2289475) 2289475..2289555 + 81 Protein_2290 hypothetical protein -
KQ261_RS26395 (2289844) 2289844..2289924 - 81 WP_023441679.1 hypothetical protein -
KQ261_RS26400 (2289903) 2289903..2290226 + 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KQ261_RS11625 (2290327) 2290327..2290656 - 330 WP_000450409.1 DUF496 family protein -
KQ261_RS11630 (2290828) 2290828..2291886 - 1059 WP_001200889.1 FUSC family protein -
KQ261_RS11635 (2292084) 2292084..2292557 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KQ261_RS11640 (2292676) 2292676..2293842 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T206282 WP_000854815.1 NZ_CP076693:2288864-2289238 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T206282 NZ_CP102330:c409922-409605 [Burkholderia cepacia]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACGCATGGTTTGCCGGCCTGCGGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCGGGCTCGCCGG
TCGTCGAAATGCGGATCGACCACGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT206282 WP_001280918.1 NZ_CP076693:2288407-2288775 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT206282 NZ_CP102330:c409601-409302 [Burkholderia cepacia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACC
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCAAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References