Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1692048..1693636 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag KQ261_RS08425 Protein ID WP_001125411.1
Coordinates 1692048..1693370 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag KQ261_RS08430 Protein ID WP_001296076.1
Coordinates 1693370..1693636 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS08415 (1689502) 1689502..1690212 - 711 WP_001195176.1 fimbria/pilus periplasmic chaperone -
KQ261_RS08420 (1690574) 1690574..1691137 - 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
KQ261_RS08425 (1692048) 1692048..1693370 - 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
KQ261_RS08430 (1693370) 1693370..1693636 - 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KQ261_RS08435 (1693944) 1693944..1694702 + 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
KQ261_RS08440 (1694706) 1694706..1695620 - 915 WP_001296077.1 bestrophin family protein -
KQ261_RS08445 (1695817) 1695817..1697268 - 1452 WP_000854638.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T206273 WP_001125411.1 NZ_CP076693:c1693370-1692048 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

>T206273 NZ_CP102325:c854312-852996 [Aeromonas dhakensis]
ATGATGAATGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAATCAGCTGATTGGCCATCTCGAATATGACTCCAA
CCGGGATTCGTTTCAGCTCGGCTATCTGCCAGAGTGGCAAGCGCGCGGATTCCCACTCTCACCGCCACTGGCGTTGGATG
GCTCGGCCAGCAGCGCTCAGATCCGGGCGTATCTCGGCAACTTACTGCCAGAAAATCGCGGGCTGGATCATCTGATTGAG
GTACTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTAATCCACGGTATCGGCCGCGATGTATCCGGGGCTGTCACCTTCAC
CCTACCCGCAGAGCCCGACATTCCCACCCGGTTTCGCCCCATCACACCAGAGGAGTTGATGCTGCGCCTCGATCAACCCG
AGATTTGGCCGCTGGAAGTCTGGGATGGCCGCCCCCGACTCTCGGTTGCGGGTGTGCAGGCCAAACTCAACCTGCTGCGA
CTCGAGGGGAGGCTAGGATTTGGCGAAGGTGAACTCTGTTCAACCCACCTCCTCAAGTTCGAGCATCACCCTCATCTAGT
GATCAATGAATTTGTAACCATGCAGCTGGCCGCACAGCTTAGCATGCCGGTGGCGCGGGTCGAACTGCATACTGTGGGTC
AGGATGAGAAGTCCCACAGAAGCTTGCTGGTGGAACGGTTCGACCGTCGTCTTGATGAGGATGGCATGAGGGTCCGCCGT
CGCCACATGATCGATGCCTGTCAGGGGCTGGGGTTCCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGATGGTCGGGA
CGTGGCCCATATTCGGGAAGGGGTGAGCCTGCCACGGCTGTTCAGCCTTAGCGCTCTCTGCGTCAATCCAGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAATCACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGACGCCCACCCCTTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAACCAGCATCT
GGCCATGGCCATAGGCGACGAATTTGCTCCCGAGGCGATCAACGCATGGCAGTTGCTGGAAATGGCCGAGGCATGTGACC
TACCCGAACGCCTGCTGCAACAGACCTTGCAGAAGATAGCCAGCGACATCCTCCACCATTTGGATGCCGCTATAGCCATG
GTCGAGACAGACCATCCCGCCGAGCTGGATTATCTAGCACGCTATAAAGATGACGTTAAGCGCCGTTGCCACCATTTTCA
GGAGCAGGCGGGGCTGTTGCCCGAACTGCAGCTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT206273 WP_001296076.1 NZ_CP076693:c1693636-1693370 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT206273 NZ_CP102325:c854589-854296 [Aeromonas dhakensis]
ATGACAGATACACCGTTGCCAACCGGCACGAAAGAACTGGATCCCGCCTCGCTGGGACTGGCGATACGGGAGAGACGCAA
AGCAGCCAAGATGACCCAAGAGGTGACGGCCTCACTGTGCGGCATCTCCAAGAAAACCCTGATCAAGATTGAAAAAGGGG
GGGATGTCTACCTCTCGACCCTGCTGCAGGTGATGAAGGCGCTGGGACTGAGGTTGCAACTGGTGCAAGAAGCGGGATCA
CAGGTAATGAGCAGCTACAGCCAACCAGAGGTCGGTGATGATGAATGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References