Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4000638..4001269 Replicon chromosome
Accession NZ_CP076679
Organism Rhodopseudomonas palustris strain VNW64

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KQX61_RS18595 Protein ID WP_264052865.1
Coordinates 4000638..4001042 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KQX61_RS18600 Protein ID WP_264052866.1
Coordinates 4001039..4001269 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQX61_RS18580 (KQX61_18485) 3995652..3995894 - 243 WP_011159021.1 hypothetical protein -
KQX61_RS18585 (KQX61_18490) 3996231..3997454 + 1224 WP_264052864.1 efflux RND transporter periplasmic adaptor subunit -
KQX61_RS18590 (KQX61_18495) 3997457..4000594 + 3138 WP_164635628.1 multidrug efflux RND transporter permease subunit -
KQX61_RS18595 (KQX61_18500) 4000638..4001042 - 405 WP_264052865.1 PIN domain-containing protein Toxin
KQX61_RS18600 (KQX61_18505) 4001039..4001269 - 231 WP_264052866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KQX61_RS18610 (KQX61_18515) 4001839..4002138 + 300 WP_264052867.1 nucleotidyltransferase substrate binding protein -
KQX61_RS18615 (KQX61_18520) 4002135..4002467 + 333 WP_264052868.1 nucleotidyltransferase domain-containing protein -
KQX61_RS18620 (KQX61_18525) 4002478..4003671 - 1194 WP_264052869.1 CoA transferase -
KQX61_RS18625 (KQX61_18530) 4003777..4004988 - 1212 WP_264052870.1 ABC transporter substrate-binding protein -
KQX61_RS18630 (KQX61_18535) 4005231..4005845 - 615 WP_264052871.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-114)

Antitoxin

SpoVT-AbrB domain

(5-42)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14565.47 Da        Isoelectric Point: 4.7423

>T206199 WP_264052865.1 NZ_CP076679:c4001042-4000638 [Rhodopseudomonas palustris]
VTAFFDTDILVHDQETGAKADRARAVLGGGGRLSVQVLNEFTVVVQRKFGRGWREIAEAIDDALAVSGPPLPLTQDLHVA
ARVLAETCKLSFYDALIVAAAQEAGCEVLYSEDLQHGRSFGTLRVENPFLENPR

Download         Length: 405 bp

>T206199 NZ_CP102189:4194-4508 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8911.13 Da        Isoelectric Point: 6.3983

>AT206199 WP_264052866.1 NZ_CP076679:c4001269-4001039 [Rhodopseudomonas palustris]
MKVSRWGNSLAVRLPNALVDKLDLKEGDELNVVDVAERTVVVEKEDRRKAALERMAERKWKLPEGYRFDRDEANER

Download         Length: 231 bp

>AT206199 NZ_CP102189:3928-4206 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References